دورية أكاديمية
أعرض في EDS

Risk of arboviral transmission and insecticide resistance status of Aedes mosquitoes during a yellow fever outbreak in Ghana.

التفاصيل البيبلوغرافية
العنوان: Risk of arboviral transmission and insecticide resistance status of Aedes mosquitoes during a yellow fever outbreak in Ghana.
المؤلفون: Owusu-Akyaw M; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Owusu-Asenso CM; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Abdulai A; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Mohammed AR; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Sraku IK; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Boadu EN; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Aduhene E; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Attah SK; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana., Afrane YA; Centre for Vector-Borne Disease Research, Department of Medical Microbiology, Medical School, University of Ghana, Accra, Ghana. yafrane@ug.edu.gh.
المصدر: BMC infectious diseases [BMC Infect Dis] 2024 Jul 25; Vol. 24 (1), pp. 731. Date of Electronic Publication: 2024 Jul 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Aedes*/virology , Aedes*/drug effects , Aedes*/genetics , Insecticide Resistance*/genetics , Disease Outbreaks* , Yellow Fever*/transmission , Yellow Fever*/epidemiology , Mosquito Vectors*/virology , Mosquito Vectors*/genetics , Mosquito Vectors*/drug effects , Insecticides*/pharmacology, Animals ; Ghana/epidemiology ; Humans ; Female ; Yellow fever virus/genetics ; Yellow fever virus/drug effects
مستخلص: Background: In late 2021, Ghana was hit by a Yellow Fever outbreak that started in two districts in the Savannah region and spread to several other Districts in three regions. Yellow fever is endemic in Ghana. However, there is currently no structured vector control programme for Aedes the arboviral vector in Ghana. Knowledge of Aedes bionomics and insecticide susceptibility status is important to control the vectors. This study therefore sought to determine Aedes vector bionomics and their insecticide resistance status during a yellow fever outbreak.
Methods: The study was performed in two yellow fever outbreak sites (Wenchi, Larabanga) and two non-outbreak sites (Kpalsogu, Pagaza) in Ghana. Immature Aedes mosquitoes were sampled from water-holding containers in and around human habitations. The risk of disease transmission was determined in each site using stegomyia indices. Adult Aedes mosquitoes were sampled using Biogents Sentinel (BG) traps, Human Landing Catch (HLC), and Prokopack (PPK) aspirators. Phenotypic resistance to permethrin, deltamethrin and pirimiphos-methyl was determined with WHO susceptibility tests using Aedes mosquitoes collected as larvae and reared into adults. Knockdown resistance (kdr) mutations were detected using allele-specific multiplex PCR.
Results: Among the 2,664 immature Aedes sampled, more than 60% were found in car tyres. Larabanga, an outbreak site, was classified as a high-risk zone for the Yellow Fever outbreak (BI: 84%, CI: 26.4%). Out of 1,507 adult Aedes mosquitoes collected, Aedes aegypti was the predominant vector species (92%). A significantly high abundance of Aedes mosquitoes was observed during the dry season (61.2%) and outdoors (60.6%) (P < 0.001). Moderate to high resistance to deltamethrin was observed in all sites (33.75% to 70%). Moderate resistance to pirimiphos-methyl (65%) was observed in Kpalsogu. Aedes mosquitoes from Larabanga were susceptible (98%) to permethrin. The F1534C kdr, V1016I kdr and V410 kdr alleles were present in all the sites with frequencies between (0.05-0.92). The outbreak sites had significantly higher allele frequencies of F1534C and V1016I respectively compared to non-outbreak sites (P < 0.001).
Conclusion: This study indicates that Aedes mosquitoes in Ghana pose a significant risk to public health. Hence there is a need to continue monitoring these vectors to develop an effective control strategy.
(© 2024. The Author(s).)
التعليقات: Update of: Res Sq. 2024 Apr 19:rs.3.rs-4271509. doi: 10.21203/rs.3.rs-4271509/v1. (PMID: 38699327)
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معلومات مُعتمدة: D43 TW011513 United States TW FIC NIH HHS; D43 TW 011513 United States NH NIH HHS
فهرسة مساهمة: Keywords: Aedes aegypti; Ghana; Stegomyia indices; Yellow fever
المشرفين على المادة: 0 (Insecticides)
تواريخ الأحداث: Date Created: 20240725 Date Completed: 20240726 Latest Revision: 20240730
رمز التحديث: 20240730
مُعرف محوري في PubMed: PMC11270840
DOI: 10.1186/s12879-024-09643-z
PMID: 39054464
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-024-09643-z