دورية أكاديمية
Independent Risk Factors of Failed Extubation among Adult Critically Ill Patients: A Prospective Observational Study from Saudi Arabia.
| العنوان: | Independent Risk Factors of Failed Extubation among Adult Critically Ill Patients: A Prospective Observational Study from Saudi Arabia. |
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| المؤلفون: | Al-Ali AH; Respiratory Care Administration, King Saud Medical City, Riyadh, Saudi Arabia., Alraeyes KA; Respiratory Care Administration, King Saud Medical City, Riyadh, Saudi Arabia., Julkarnain PR; Respiratory Care Administration, King Saud Medical City, Riyadh, Saudi Arabia., Lakshmanan AP; Respiratory Care Administration, King Saud Medical City, Riyadh, Saudi Arabia., Alobaid A; Respiratory Care Administration, King Saud Medical City, Riyadh, Saudi Arabia., Aljoni AY; Respiratory Care Administration, King Saud Medical City, Riyadh, Saudi Arabia., Saleem NH; Respiratory Care Administration, King Saud Medical City, Riyadh, Saudi Arabia., Al Odat MA; Critical Care Department, King Saud Medical City, Riyadh, Saudi Arabia., Aletreby WT; Critical Care Department, King Saud Medical City, Riyadh, Saudi Arabia. |
| المصدر: | Saudi journal of medicine & medical sciences [Saudi J Med Med Sci] 2024 Jul-Sep; Vol. 12 (3), pp. 216-222. Date of Electronic Publication: 2024 Jun 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer - Medknow Publications Country of Publication: India NLM ID: 101675905 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2321-4856 (Electronic) Linking ISSN: 23214856 NLM ISO Abbreviation: Saudi J Med Med Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Mumbai : Wolters Kluwer - Medknow Publications, [2013]- |
| مستخلص: | Background: Mechanical ventilation provides essential support for critically ill patients in several diagnoses; however, extubation failure can affect patient outcomes. From Saudi Arabia, no study has assessed the factors associated with extubation failure in adults. Methods: This prospective observational study was conducted in the intensive care unit of a tertiary care hospital in Riyadh, Saudi Arabia. Adult patients who had been mechanically ventilated via the endotracheal tube for a minimum of 24 hours and then extubated according to the weaning protocol were included. Failed extubation was defined as reintubation within 48 hours of extubation. Results: A total of 505 patients were included, of which 72 patients had failed extubation (14.3%, 95% CI: 11.4%-17.7%). Compared with the failed extubation group, the successfully extubated group had significantly shorter duration of mechanical ventilation (mean difference: -2.6 days, 95% CI: -4.3 to -1; P = 0.001), a slower respiratory rate at the time of extubation (mean difference: -2.3 breath/min, 95% CI: -3.8 to -1; P = 0.0005), higher pH (mean difference: 0.02, 95% CI: 0.001-0.04; P = 0.03), and more patients with strong cough (percent difference: 17.7%, 95% CI: 4.8%-30.5%; P = 0.02). Independent risk factors of failed extubation were age (aOR = 1.02; 95% CI: 1.002-1.03; P = 0.03), respiratory rate (aOR = 1.06, 95% CI: 1.01-1.1; P = 0.008), duration of mechanical ventilation (aOR = 1.08, 95% CI: 1.03 - 1.1; P < 0.001), and pH (aOR = 0.02, 95% CI: 0.0006-0.5; P = 0.02). Conclusion: Older age, longer duration of mechanical ventilation, faster respiratory rate, and lower pH were found to be independent risk factors that significantly increased the odds of extubation failure among adults. Competing Interests: There are no conflicts of interest. (Copyright: © 2024 Saudi Journal of Medicine & Medical Sciences.) |
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| فهرسة مساهمة: | Keywords: Adverse effects; airway extubation; critically ill; mechanical ventilation; reintubation; risk factors |
| تواريخ الأحداث: | Date Created: 20240726 Latest Revision: 20240727 |
| رمز التحديث: | 20240727 |
| مُعرف محوري في PubMed: | PMC11268545 |
| DOI: | 10.4103/sjmms.sjmms_19_24 |
| PMID: | 39055080 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2321-4856 |
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| DOI: | 10.4103/sjmms.sjmms_19_24 |