دورية أكاديمية
أعرض في EDS

Prevalence of chronic kidney disease and associated risk factors among people living with HIV in a rural population of Limpopo Province, South Africa.

التفاصيل البيبلوغرافية
العنوان: Prevalence of chronic kidney disease and associated risk factors among people living with HIV in a rural population of Limpopo Province, South Africa.
المؤلفون: Choshi J; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, South Africa., Flepisi B; Department of Pharmacology, University of Pretoria, Pretoria, South Africa., Mabhida SE; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa., Sekgala MD; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa., Mokoena H; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, South Africa., Nkambule BB; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Ndwandwe D; Cochrane South Africa, South African Medical Research Council, Tygerberg, South Africa., Mchiza ZJ; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa.; School of Public Health, University of the Western Cape, Bellville, South Africa., Nqebelele U; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa.; Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa., Kengne AP; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa., Dludla PV; Cochrane South Africa, South African Medical Research Council, Tygerberg, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa., Hanser S; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, South Africa.
المصدر: Frontiers in public health [Front Public Health] 2024 Jul 11; Vol. 12, pp. 1425460. Date of Electronic Publication: 2024 Jul 11 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Editorial Office
مواضيع طبية MeSH: Renal Insufficiency, Chronic*/epidemiology , HIV Infections*/epidemiology , HIV Infections*/complications , Rural Population*/statistics & numerical data, Humans ; Male ; Female ; South Africa/epidemiology ; Cross-Sectional Studies ; Risk Factors ; Prevalence ; Adult ; Middle Aged ; Glomerular Filtration Rate ; Surveys and Questionnaires
مستخلص: Background: Limited evidence informs on the prevalence of chronic kidney disease (CKD) in people living with HIV (PLWH) in South Africa. Thus, this study aimed to determine the prevalence of CKD and its associated risk factors among PLWH within the rural province of Limpopo, South Africa.
Methods: We conducted a cross-sectional study of 143 participants, subdivided into groups of PLWH ( n  = 103) and individuals without HIV ( n  = 43). Structured questionnaires were used to collect and capture sociodemographic information including age, sex, alcohol intake, smoking status, and educational status. Basic measurements taken included levels of cluster of differentiation 4 (CD4+) count, body mass index (BMI), blood pressure, plasma cystatin C, and fasting serum glucose levels. Plasma cystatin C-based estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD-EPI) estimator to determine the prevalence of CKD.
Results: The prevalence of CKD was approximately 7% in PLWH. Multivariate logistic regression analysis showed that it was only diabetes mellitus (odds ratio of 5.795, 95% confidence interval, p  = 0.034) and age (odds ratio of 1.078, 95% confidence interval, p  = 0.039) that were significantly associated with CKD in PLWH.
Conclusion: Chronic kidney disease was prevalent in PLWH, and it was further associated with cardiovascular risk factors, diabetes, and ageing. As PLWH age, the burden of CKD may be increased with the increase in cardiovascular-related comorbidities such as diabetes.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(Copyright © 2024 Choshi, Flepisi, Mabhida, Sekgala, Mokoena, Nkambule, Ndwandwe, Mchiza, Nqebelele, Kengne, Dludla and Hanser.)
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فهرسة مساهمة: Keywords: chronic kidney disease; individuals without HIV; people living with HIV; prevalence; risk factors
تواريخ الأحداث: Date Created: 20240726 Date Completed: 20240726 Latest Revision: 20240727
رمز التحديث: 20240727
مُعرف محوري في PubMed: PMC11269117
DOI: 10.3389/fpubh.2024.1425460
PMID: 39056083
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-2565
DOI:10.3389/fpubh.2024.1425460