دورية أكاديمية
Differences in corneal nerve fiber density and fiber length in patients with painful chronic idiopathic axonal polyneuropathy and diabetic polyneuropathy.
العنوان: | Differences in corneal nerve fiber density and fiber length in patients with painful chronic idiopathic axonal polyneuropathy and diabetic polyneuropathy. |
---|---|
المؤلفون: | Nieuwenhoff MD; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Centre for Human Drug Research, Leiden, The Netherlands., Nguyen HT; Department of Ophthalmology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands., Niehof SP; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Huygen FJPM; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Verma A; Biogen, Cambridge, Massachusetts, USA., Klaassen ES; Centre for Human Drug Research, Leiden, The Netherlands., Bechakra M; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Geelhoed WJ; Centre for Human Drug Research, Leiden, The Netherlands., Jongen JLM; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Moll AC; Department of Ophthalmology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands., Vrancken AFJE; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands., Petzold A; Department of Ophthalmology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands.; Department of Neurology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands.; Moorfields Eye Hospital, The National Hospital for Neurology and Neurosurgery and the Queen Square Institute of Neurology, UCL, London, UK., Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands. |
المصدر: | Muscle & nerve [Muscle Nerve] 2024 Jul 26. Date of Electronic Publication: 2024 Jul 26. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 7803146 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4598 (Electronic) Linking ISSN: 0148639X NLM ISO Abbreviation: Muscle Nerve Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2005-> : Hoboken, NJ : John Wiley & Sons Original Publication: New York, NY : John Wiley & Sons |
مستخلص: | Introduction/aims: Corneal confocal microscopy (CCM) detects small nerve fiber loss and correlates with skin biopsy findings in diabetic neuropathy. In chronic idiopathic axonal polyneuropathy (CIAP) this correlation is unknown. Therefore, we compared CCM and skin biopsy in patients with CIAP to healthy controls, patients with painful diabetic neuropathy (PDN) and diabetics without overt neuropathy (DM). Methods: Participants with CIAP and suspected small fiber neuropathy (n = 15), PDN (n = 16), DM (n = 15), and healthy controls (n = 16) underwent skin biopsy and CCM testing. Inter-center intraclass correlation coefficients (ICC) were calculated for CCM parameters. Results: Compared with healthy controls, patients with CIAP and PDN had significantly fewer nerve fibers in the skin (IENFD: 5.7 ± 2.3, 3.0 ± 1.8, 3.9 ± 1.5 fibers/mm, all p < .05). Corneal nerve parameters in CIAP (fiber density 23.8 ± 4.9 no./mm 2 , branch density 16.0 ± 8.8 no./mm 2 , fiber length 13.1 ± 2.6 mm/mm 2 ) were not different from healthy controls (24.0 ± 6.8 no./mm 2 , 22.1 ± 9.7 no./mm 2 , 13.5 ± 3.5 mm/mm 2 , all p > .05). In patients with PDN, corneal nerve fiber density (17.8 ± 5.7 no./mm 2 ) and fiber length (10.5 ± 2.7 mm/mm 2 ) were reduced compared with healthy controls (p < .05). CCM results did not correlate with IENFD in CIAP patients. Inter-center ICC was 0.77 for fiber density and 0.87 for fiber length. Discussion: In contrast to patients with PDN, corneal nerve parameters were not decreased in patients with CIAP and small nerve fiber damage. Therefore, CCM is not a good biomarker for small nerve fiber loss in CIAP patients. (© 2024 The Author(s). Muscle & Nerve published by Wiley Periodicals LLC.) |
References: | Visser NA, Notermans NC, Linssen RS, van den Berg LH, Vrancken AF. Incidence of polyneuropathy in Utrecht, the Netherlands. Neurology. 2015;84(3):259‐264. de Schryver EL, van Schelven LJ, Notermans NC, de Valk HW, Oey PL. Small‐fibre neuropathy can be detected in patients with chronic idiopathic axonal polyneuropathy. Eur J Neurol. 2011;18(7):1003‐1005. Erdmann PG, van Genderen FR, Teunissen LL, et al. Pain in patients with chronic idiopathic axonal polyneuropathy. Eur Neurol. 2010;64(1):58‐64. Bechakra M, Nieuwenhoff MD, van Rosmalen J, et al. Pain‐related changes in cutaneous innervation of patients suffering from bortezomib‐induced, diabetic or chronic idiopathic axonal polyneuropathy. Brain Res. 2020;1730:146621. Lauria G, Hsieh ST, Johansson O, et al. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol. 2010;17(7):903‐912. Argyriou AA, Park SB, Islam B, et al. Neurophysiological, nerve imaging and other techniques to assess chemotherapy‐induced peripheral neurotoxicity in the clinical and research settings. J Neurol Neurosurg Psychiatry. 2019;90(12):1361‐1369. Tavakoli M, Ferdousi M, Petropoulos IN, et al. Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Diabetes Care. 2015;38(5):838‐843. Tavakoli M, Quattrini C, Abbott C, et al. Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care. 2010;33(8):1792‐1797. Ahmed A, Bril V, Orszag A, et al. Detection of diabetic sensorimotor polyneuropathy by corneal confocal microscopy in type 1 diabetes: a concurrent validity study. Diabetes Care. 2012;35(4):821‐828. Ziegler D, Papanas N, Zhivov A, et al. Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes. Diabetes. 2014;63(7):2454‐2463. Gemignani F, Ferrari G, Vitetta F, Giovanelli M, Macaluso C, Marbini A. Non‐length‐dependent small fibre neuropathy. Confocal microscopy study of the corneal innervation. J Neurol Neurosurg Psychiatry. 2010;81(7):731‐733. Tavakoli M, Marshall A, Banka S, et al. Corneal confocal microscopy detects small‐fiber neuropathy in Charcot–Marie–Tooth disease type 1A patients. Muscle Nerve. 2012;46(5):698‐704. Petropoulos IN, Al‐Mohammedi A, Chen X, et al. The utility of corneal nerve fractal dimension analysis in peripheral neuropathies of different etiology. Transl Vis Sci Technol. 2020;9(9):43. Merkies IS, Faber CG, Lauria G. Advances in diagnostics and outcome measures in peripheral neuropathies. Neurosci Lett. 2015;596:3‐13. Quattrini C, Tavakoli M, Jeziorska M, et al. Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes. 2007;56(8):2148‐2154. Visser NA, Vrancken AF, van der Schouw YT, van den Berg LH, Notermans NC. Chronic idiopathic axonal polyneuropathy is associated with the metabolic syndrome. Diabetes Care. 2013;36(4):817‐822. Herman WH, Pop‐Busui R, Braffett BH, et al. Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in type 1 diabetes: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications. Diabet Med. 2012;29(7):937‐944. Bril V. NIS‐LL: the primary measurement scale for clinical trial endpoints in diabetic peripheral neuropathy. Eur Neurol. 1999;41(suppl 1):8‐13. Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W. COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin Proc. 2012;87(12):1196‐1201. McCarthy BG, Hsieh ST, Stocks A, et al. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology. 1995;45(10):1848‐1855. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202‐207. Kalteniece A, Ferdousi M, Adam S, et al. Corneal confocal microscopy is a rapid reproducible ophthalmic technique for quantifying corneal nerve abnormalities. PLoS One. 2017;12(8):e0183040. Bland JM, Altman DG. A note on the use of the intraclass correlation coefficient in the evaluation of agreement between two methods of measurement. Comput Biol Med. 1990;20(5):337‐340. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1(8476):307‐310. Nebuchennykh M, Loseth S, Jorde R, Mellgren SI. Idiopathic polyneuropathy and impaired glucose metabolism in a Norwegian patient series. Eur J Neurol. 2008;15(8):810‐816. Raasing LRM, Vogels OJM, Datema M, Tannemaat MR, Veltkamp M, Grutters JC. Fully automatic, semiautomatic, and manual corneal nerve fiber analysis in patients with sarcoidosis. Transl Vis Sci Technol. 2023;12(12):3. Giannaccare G, Pellegrini M, Sebastiani S, Moscardelli F, Versura P, Campos EC. In vivo confocal microscopy morphometric analysis of corneal subbasal nerve plexus in dry eye disease using newly developed fully automated system. Graefes Arch Clin Exp Ophthalmol. 2019;257(3):583‐589. Perkins BA, Lovblom LE, Bril V, et al. Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study. Diabetologia. 2018;61(8):1856‐1861. Dabbah MA, Graham J, Petropoulos IN, Tavakoli M, Malik RA. Automatic analysis of diabetic peripheral neuropathy using multi‐scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging. Med Image Anal. 2011;15(5):738‐747. Petropoulos IN, Alam U, Fadavi H, et al. Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Invest Ophthalmol Vis Sci. 2014;55(4):2071‐2078. Sivaskandarajah GA, Halpern EM, Lovblom LE, et al. Structure‐function relationship between corneal nerves and conventional small‐fiber tests in type 1 diabetes. Diabetes Care. 2013;36(9):2748‐2755. Gylfadottir SS, Itani M, Kristensen AG, et al. Assessing corneal confocal microscopy and other small fiber measures in diabetic polyneuropathy. Neurology. 2023;100(16):e1680‐e1690. Kass‐Iliyya L, Javed S, Gosal D, et al. Small fiber neuropathy in Parkinson's disease: a clinical, pathological and corneal confocal microscopy study. Parkinsonism Relat Disord. 2015;21(12):1454‐1460. Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt NA. Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type‐1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst. 2013;18(4):306‐315. Gemignani F, Bellanova MF, Saccani E, Pavesi G. Non‐length‐dependent small fiber neuropathy: not a matter of stockings and gloves. Muscle Nerve. 2022;65(1):10‐28. Tavakoli M, Begum P, McLaughlin J, Malik RA. Corneal confocal microscopy for the diagnosis of diabetic autonomic neuropathy. Muscle Nerve. 2015;52(3):363‐370. Maddaloni E, Sabatino F, Del Toro R, et al. In vivo corneal confocal microscopy as a novel non‐invasive tool to investigate cardiac autonomic neuropathy in type 1 diabetes. Diabet Med. 2015;32(2):262‐266. Thaisetthawatkul P, Lyden E, Americo Fernandes J Jr, Herrmann DN. Prediabetes, diabetes, metabolic syndrome, and small fiber neuropathy. Muscle Nerve. 2020;61(4):475‐479. Kazamel M, Stino AM, Smith AG. Metabolic syndrome and peripheral neuropathy. Muscle Nerve. 2021;63(3):285‐293. Tesfaye S, Boulton AJ, Dyck PJ, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285‐2293. Malik RA, Tesfaye S, Newrick PG, et al. Sural nerve pathology in diabetic patients with minimal but progressive neuropathy. Diabetologia. 2005;48(3):578‐585. Cosmo E, Midena G, Frizziero L, Bruno M, Cecere M, Midena E. Corneal confocal microscopy as a quantitative imaging biomarker of diabetic peripheral neuropathy: a review. J Clin Med. 2022;11(17):5130. Emanuel AL, Nieuwenhoff MD, Klaassen ES, et al. Relationships between type 2 diabetes, neuropathy, and microvascular dysfunction: evidence from patients with cryptogenic axonal polyneuropathy. Diabetes Care. 2017;40(4):583‐590. Ostrovski I, Lovblom LE, Farooqi MA, et al. Reproducibility of in vivo corneal confocal microscopy using an automated analysis program for detection of diabetic sensorimotor polyneuropathy. PLoS One. 2015;10(11):e0142309. Petropoulos IN, Manzoor T, Morgan P, et al. Repeatability of in vivo corneal confocal microscopy to quantify corneal nerve morphology. Cornea. 2013;32(5):e83‐e89. Hertz P, Bril V, Orszag A, et al. Reproducibility of in vivo corneal confocal microscopy as a novel screening test for early diabetic sensorimotor polyneuropathy. Diabet Med. 2011;28(10):1253‐1260. Pacaud D, Romanchuk KG, Tavakoli M, et al. The reliability and reproducibility of corneal confocal microscopy in children. Invest Ophthalmol Vis Sci. 2015;56(9):5636‐5640. |
معلومات مُعتمدة: | 10730 Dutch Technology Foundation STW; Biogen |
فهرسة مساهمة: | Keywords: chronic idiopathic axonal polyneuropathy; corneal confocal microscopy; diabetic neuropathy; intra epidermal nerve fiber density; pain |
تواريخ الأحداث: | Date Created: 20240726 Latest Revision: 20240726 |
رمز التحديث: | 20240726 |
DOI: | 10.1002/mus.28213 |
PMID: | 39056231 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1097-4598 |
---|---|
DOI: | 10.1002/mus.28213 |