دورية أكاديمية
أعرض في EDS

Prevalence of Cryptococcal Antigenemia and Lateral Flow Assay Accuracy in Severely Immunosuppressed AIDS Patients.

التفاصيل البيبلوغرافية
العنوان: Prevalence of Cryptococcal Antigenemia and Lateral Flow Assay Accuracy in Severely Immunosuppressed AIDS Patients.
المؤلفون: Negri ACG; Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.; Maria Aparecida Pedrossian University Hospital, Federal University of Mato Grosso do Sul, Campo Grande 79080-190, MS, Brazil., Nunes MO; Maria Aparecida Pedrossian University Hospital, Federal University of Mato Grosso do Sul, Campo Grande 79080-190, MS, Brazil., Lima GME; Maria Aparecida Pedrossian University Hospital, Federal University of Mato Grosso do Sul, Campo Grande 79080-190, MS, Brazil., Venturini J; Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., de Oliveira SMDVL; Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.; Oswaldo Cruz Foundation, Campo Grande 79081-746, MS, Brazil., Lazera MDS; National Institute of Infectious Diseases Evandro Chagas, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, Brazil., Carvalho LR; Department of Biostatistics, Plant Biology, Parasitology and Zoology, Bioscience Institute, São Paulo State University, Campus de Botucatu, Botucatu 18618-687, SP, Brazil., Chang MR; Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Tsujisaki RAS; Department of Nutrition, Health Sciences Center, UFB-Universidade Federal da Paraíba, João Pessoa 58091-900, PB, Brazil., França AO; Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Mendes RP; Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.; Department of Tropical Diseases, Botucatu Medical School, São Paulo State University, Botucatu 18618-687, SP, Brazil., Paniago AMM; Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.
المصدر: Journal of fungi (Basel, Switzerland) [J Fungi (Basel)] 2024 Jul 16; Vol. 10 (7). Date of Electronic Publication: 2024 Jul 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101671827 Publication Model: Electronic Cited Medium: Internet ISSN: 2309-608X (Electronic) Linking ISSN: 2309608X NLM ISO Abbreviation: J Fungi (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2015]-
مستخلص: This study aimed to estimate the prevalence of cryptococcal antigenemia detected by lateral flow assay (LFA) in AIDS patients and its accuracy in the diagnosis of cryptococcosis. Conducted at a university hospital in Brazil from March 2015 to July 2017, it included AIDS patients over 18 years old with a CD4+ count ≤ 200 cells/mm 3 . Cryptococcal antigen (CrAg) detection using LFA and latex agglutination (LA), along with blood and urine cultures, were performed. The reference standard was the identification of Cryptococcus spp. in clinical specimens through microbiological or histopathological examination. Among 230 patients, the prevalence of CrAg detected by LFA (CrAg LFA) was 13.0%. Factors associated with cryptococcal antigenemia included fever, vomiting, seizures, and a lack of antiretroviral therapy. The sensitivity and specificity of CrAg LFA were 83.9% and 98.0%, respectively. The positive predictive value (PPV) was 86.7%, the negative predictive value (NPV) was 97.5%, and overall accuracy was 96.1%. Cross-reactions were observed in patients with histoplasmosis and paracoccidioidmycosis, but not with aspergillosis or positive rheumatoid factor. The study concludes that the LFA is a useful tool for detecting cryptococcal antigenemia in severely immunocompromised AIDS patients due to its high NPV, specificity, and PPV.
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معلومات مُعتمدة: 1 United States CX CSRD VA; 312910/2020-7 and 422757/2021-7 National Council for Scientific and Technological Development; 59/300.033/2015; 71/000.478/2021; 71/038.790/2022 Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
فهرسة مساهمة: Keywords: HIV infection; cryptococcosis; immunocromatography; point-of-care systems
تواريخ الأحداث: Date Created: 20240726 Latest Revision: 20240728
رمز التحديث: 20240728
مُعرف محوري في PubMed: PMC11278224
DOI: 10.3390/jof10070490
PMID: 39057375
قاعدة البيانات: MEDLINE
الوصف
تدمد:2309-608X
DOI:10.3390/jof10070490