دورية أكاديمية
أعرض في EDS

Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia.

التفاصيل البيبلوغرافية
العنوان: Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia.
المؤلفون: Cutolo EA; Laboratory of Photosynthesis and Bioenergy, Department of Biotechnology, University of Verona, Strada le Grazie 15, 37134 Verona, Italy., Campitiello R; Laboratory of Experimental Rheumatology and Academic, Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy., Caferri R; Laboratory of Photosynthesis and Bioenergy, Department of Biotechnology, University of Verona, Strada le Grazie 15, 37134 Verona, Italy., Pagliuca VF; Laboratory of Photosynthesis and Bioenergy, Department of Biotechnology, University of Verona, Strada le Grazie 15, 37134 Verona, Italy., Li J; Qingdao Innovation and Development Base, Harbin Engineering University, No. 1777 Sansha Road, Qingdao 150001, China., Agathos SN; Qingdao Innovation and Development Base, Harbin Engineering University, No. 1777 Sansha Road, Qingdao 150001, China.; Bioengineering Laboratory, Earth and Life Institute, Catholic University of Louvain, B-1348 Louvain-la-Neuve, Belgium., Cutolo M; Laboratory of Experimental Rheumatology and Academic, Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
المصدر: Marine drugs [Mar Drugs] 2024 Jun 28; Vol. 22 (7). Date of Electronic Publication: 2024 Jun 28.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Aquatic Organisms* , Drug Discovery*/methods, Humans ; Animals ; Biological Products/pharmacology ; Biological Products/chemistry ; Pharmacopoeias as Topic ; Oceans and Seas ; Immunomodulating Agents/pharmacology ; Immunomodulating Agents/chemistry ; Immunomodulating Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Immunologic Factors/pharmacology ; Immunologic Factors/chemistry
مستخلص: From sea shores to the abysses of the deep ocean, marine ecosystems have provided humanity with valuable medicinal resources. The use of marine organisms is discussed in ancient pharmacopoeias of different times and geographic regions and is still deeply rooted in traditional medicine. Thanks to present-day, large-scale bioprospecting and rigorous screening for bioactive metabolites, the ocean is coming back as an untapped resource of natural compounds with therapeutic potential. This renewed interest in marine drugs is propelled by a burgeoning research field investigating the molecular mechanisms by which newly identified compounds intervene in the pathophysiology of human diseases. Of great clinical relevance are molecules endowed with anti-inflammatory and immunomodulatory properties with emerging applications in the management of chronic inflammatory disorders, autoimmune diseases, and cancer. Here, we review the historical development of marine pharmacology in the Eastern and Western worlds and describe the status of marine drug discovery. Finally, we discuss the importance of conducting sustainable exploitation of marine resources through biotechnology.
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فهرسة مساهمة: Keywords: autoimmunity; bioprospecting; deep sea; drug discovery; genetic engineering; immunomodulation; inflammation; rheumatoid arthritis; synthetic biology; systemic sclerosis
المشرفين على المادة: 0 (Biological Products)
0 (Immunomodulating Agents)
0 (Anti-Inflammatory Agents)
0 (Immunologic Factors)
تواريخ الأحداث: Date Created: 20240726 Date Completed: 20240726 Latest Revision: 20240728
رمز التحديث: 20240728
مُعرف محوري في PubMed: PMC11278107
DOI: 10.3390/md22070304
PMID: 39057413
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md22070304