دورية أكاديمية
أعرض في EDS

Hepatitis C Virus and Molecular Mimicry.

التفاصيل البيبلوغرافية
العنوان: Hepatitis C Virus and Molecular Mimicry.
المؤلفون: Goh L; KK Women's and Children's Hospital, Singapore 229899, Singapore., Kerkar N; Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA 02114, USA.
المصدر: Pathogens (Basel, Switzerland) [Pathogens] 2024 Jun 22; Vol. 13 (7). Date of Electronic Publication: 2024 Jun 22.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2012-
مستخلص: This review delves into the interactions between hepatitis C virus (HCV) and the host immune system, shedding light on how by using the mechanism of molecular mimicry, the virus strategically evades the immune system, resulting in a cascade of diverse complications. HCV, notorious for its ability to persistently infect hepatocytes, employs molecular mimicry to resemble host proteins, thereby avoiding immune detection and mounting an effective defense. This mimicry also triggers systemic autoimmune responses that lead to various sequelae. The objective of this review is to comprehensively explore the role of HCV-induced molecular mimicry, which not only facilitates viral survival but is also instrumental in developing autoimmune and inflammatory disorders. By mimicking host proteins, HCV triggers an immune response that inadvertently attacks the host, fostering the development of autoimmune and other inflammatory disorders. Understanding the nuanced mechanisms of HCV-mediated molecular mimicry provides crucial insights into the multifaceted sequelae of viral infections on host immune responses. Unravelling these complexities is paramount for advancing therapeutic strategies that not only target the virus directly but also mitigate the secondary autoimmune and inflammatory complications induced by HCV.
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فهرسة مساهمة: Keywords: autoimmunity; hepatitis C; molecular mimicry
تواريخ الأحداث: Date Created: 20240726 Latest Revision: 20240728
رمز التحديث: 20240728
مُعرف محوري في PubMed: PMC11280050
DOI: 10.3390/pathogens13070527
PMID: 39057754
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-0817
DOI:10.3390/pathogens13070527