دورية أكاديمية
أعرض في EDS

Endocrine-Disrupting Chemicals Exposure and Neurocognitive Function in the General Population: A Community-Based Study.

التفاصيل البيبلوغرافية
العنوان: Endocrine-Disrupting Chemicals Exposure and Neurocognitive Function in the General Population: A Community-Based Study.
المؤلفون: Su FC; Department of Neurology, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Wei YC; Department of Neurology, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Sun CY; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Hsu HJ; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Lee CC; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Chen YT; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Pan HC; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Hsu CK; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Liu YA; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan., Chen CY; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
المصدر: Toxics [Toxics] 2024 Jul 17; Vol. 12 (7). Date of Electronic Publication: 2024 Jul 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101639637 Publication Model: Electronic Cited Medium: Internet ISSN: 2305-6304 (Electronic) Linking ISSN: 23056304 NLM ISO Abbreviation: Toxics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Background: Endocrine-disrupting chemicals (EDCs) are pervasive in everyday environments. The impacts of these chemicals, along with EDC-related lifestyle and dietary habits on neurocognitive function, are not well understood.
Methods: The Chang Gung Community Medicine Research Center conducted a cross-sectional study involving 887 participants. From this initial cohort, 120 individuals were selected based on their EDC exposure scores for detailed analysis. Among these, 67 participants aged 55 years or older were further chosen to undergo cognitive impairment assessments using the Ascertain Dementia-8 (AD-8) questionnaire.
Results: These 67 older participants did not significantly differ in age, albuminuria, or estimated glomerular filtration rate compared to those with lower impairment scores. This study revealed that mono-(2-ethylhexyl) phthalate (MEHP) levels (8.511 vs. 6.432 µg/g creatinine, p = 0.038) were associated with greater risk of cognitive impairment (AD-8 ≥ 2). Statistical models adjusting for age, gender, and diabetes indicated that MEHP levels positively correlated with AD-8 scores, achieving statistical significance in more comprehensive models (β ± SE: 0.160 ± 0.076, p = 0.042). Logistic regression analysis underscored a significant positive association between high MEHP levels and higher AD-8 scores (odds ratio: 1.217, p = 0.006). Receiver operating characteristic curves highlighted the association of high MEHP levels and EDC exposure scores for significant cognitive impairment, with areas under the curve of 66.3% and 66.6%, respectively.
Conclusion: Exposure to EDCs, specifically di-(2-ethylhexyl) phthalate, the precursor to MEHP, may be associated with neurocognitive impairment in middle-aged and older adults.
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معلومات مُعتمدة: CRRPG2H0132, CRRPG2H0133, CRRPG2H0134 and CLRPG2L0053 Chang Gung Memorial Hospital
فهرسة مساهمة: Keywords: dementia; endocrine-disrupting chemicals; neurocognitive disorder; paraben; phenol; phthalate
تواريخ الأحداث: Date Created: 20240726 Latest Revision: 20240728
رمز التحديث: 20240728
مُعرف محوري في PubMed: PMC11281080
DOI: 10.3390/toxics12070514
PMID: 39058166
قاعدة البيانات: MEDLINE
الوصف
تدمد:2305-6304
DOI:10.3390/toxics12070514