دورية أكاديمية
أعرض في EDS

How c-di-GMP controls progression through the Streptomyces life cycle.

التفاصيل البيبلوغرافية
العنوان: How c-di-GMP controls progression through the Streptomyces life cycle.
المؤلفون: Gallagher KA; Department of Microbiology, Cornell University, Ithaca, New York, USA., Tschowri N; Institute of Microbiology, Leibniz Universität Hannover, 30419 Hannover, Germany., Brennan RG; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Schumacher MA; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: maria.schumacher@duke.edu., Buttner MJ; Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: mark.buttner@jic.ac.uk.
المصدر: Current opinion in microbiology [Curr Opin Microbiol] 2024 Aug; Vol. 80, pp. 102516. Date of Electronic Publication: 2024 Jul 25.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Current Biology Country of Publication: England NLM ID: 9815056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0364 (Electronic) Linking ISSN: 13695274 NLM ISO Abbreviation: Curr Opin Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London ; New York : Current Biology, c1998-
مواضيع طبية MeSH: Streptomyces*/metabolism , Streptomyces*/growth & development , Streptomyces*/genetics , Cyclic GMP*/metabolism , Cyclic GMP*/analogs & derivatives , Spores, Bacterial*/growth & development , Spores, Bacterial*/metabolism , Spores, Bacterial*/genetics , Gene Expression Regulation, Bacterial* , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics, Signal Transduction
مستخلص: Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3', 5'-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized: the key developmental regulators BldD and σ WhiG , and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σ WhiG , respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
المشرفين على المادة: 61093-23-0 (bis(3',5')-cyclic diguanylic acid)
H2D2X058MU (Cyclic GMP)
0 (Bacterial Proteins)
تواريخ الأحداث: Date Created: 20240726 Date Completed: 20240812 Latest Revision: 20240812
رمز التحديث: 20240813
DOI: 10.1016/j.mib.2024.102516
PMID: 39059031
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0364
DOI:10.1016/j.mib.2024.102516