دورية أكاديمية
أعرض في EDS

Baseline 18 F-FDG PET/CT may contribute to the determination of initial treatment strategy for newly diagnosed follicular lymphoma.

التفاصيل البيبلوغرافية
العنوان: Baseline 18 F-FDG PET/CT may contribute to the determination of initial treatment strategy for newly diagnosed follicular lymphoma.
المؤلفون: Yang Q; Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Wangfujing, Dongcheng District, Beijing 100730, China; Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China. Electronic address: 77516yq@163.com., Zhang H; Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Wangfujing, Dongcheng District, Beijing 100730, China; Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China. Electronic address: zhanghongzhe@pumch.cn., Zhang Y; Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Wangfujing, Dongcheng District, Beijing 100730, China., Zhang W; Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Wangfujing, Dongcheng District, Beijing 100730, China., Zhou D; Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Wangfujing, Dongcheng District, Beijing 100730, China., Luo Y; Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Wangfujing, Dongcheng District, Beijing 100730, China; Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China; State Key Laboratory of Common Mechanism Research for Major Diseases, China. Electronic address: luoyaping@live.com.
المصدر: European journal of radiology [Eur J Radiol] 2024 Sep; Vol. 178, pp. 111632. Date of Electronic Publication: 2024 Jul 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Science Ireland Ltd
Original Publication: Stuttgart ; New York : Thieme, [c1981-
مواضيع طبية MeSH: Lymphoma, Follicular*/diagnostic imaging , Lymphoma, Follicular*/drug therapy , Fluorodeoxyglucose F18* , Positron Emission Tomography Computed Tomography*/methods , Radiopharmaceuticals*, Humans ; Female ; Male ; Middle Aged ; Aged ; Adult ; Prognosis ; Watchful Waiting ; Treatment Outcome ; Retrospective Studies
مستخلص: Background: "Watch-and-wait" approach is an important management option in asymptomatic follicular lymphoma (FL) patients with low tumor burden. Since most FL lesions are FDG-avid, we wonder if 18 F-FDG PET/CT at baseline can help to better choose the patients who can benefit from early chemotherapy. This study aimed to investigate the prognostic value of baseline 18 F-FDG PET/CT in newly diagnosed FL patients treated with either watch-and-wait approach or chemotherapy.
Results: Patients received chemotherapy as initial treatment had higher Ann Arbor stage, higher incidence of extranodal involvement and bulky disease, more involved lymph nodes larger than 3 cm, and higher SUVmax, MTV, and TLG than those managed with watch-and-wait approach (p < 0.05). The median PFS and TTNT in patients received chemotherapy and under watch-and-wait did not show significant difference, however patients with MTV<111.66 mL or TLG<141.50 SUVbw*mL had significantly longer PFS and TTNT than those patients with MTV≥111.66 mL or TLG≥141.50 SUVbw*mL (p < 0.05). Further analysis revealed that for patients with TLG≥141.50 SUVbw*mL or MTV≥111.66 mL, those who received chemotherapy as initial treatment had a significantly longer PFS and TTNT than those managed with initial watch-and-wait approach (p < 0.05). However, for patients with MTV<111.66 mL or TLG<141.50 SUVbw*mL in baseline PET/CT, there was no significant difference in PFS or TTNT between patients who received chemotherapy and those under watch-and-wait.
Conclusion: Baseline 18 F-FDG PET/CT may provide prognostic value and help to improve the decision-making of initial treatment plans for newly diagnosed FL patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: (18)F-FDG; Follicular lymphoma; PET/CT
المشرفين على المادة: 0Z5B2CJX4D (Fluorodeoxyglucose F18)
0 (Radiopharmaceuticals)
تواريخ الأحداث: Date Created: 20240726 Date Completed: 20240816 Latest Revision: 20240816
رمز التحديث: 20240818
DOI: 10.1016/j.ejrad.2024.111632
PMID: 39059082
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7727
DOI:10.1016/j.ejrad.2024.111632