دورية أكاديمية
Risk Factors for Non-sentinel Lymph Node Metastasis in HR+/HER2- Breast Cancer With cN0.
| العنوان: | Risk Factors for Non-sentinel Lymph Node Metastasis in HR+/HER2- Breast Cancer With cN0. |
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| المؤلفون: | Na YM; Department of Surgery, Chonnam National University Medical School & Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea., Park SC; Department of Surgery, Chonnam National University Medical School & Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea., Ryu YJ; Department of Surgery, Chonnam National University Medical School & Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea., Cho JS; Department of Surgery, Chonnam National University Medical School & Chonnam National University Hospital, Gwang-ju, Republic of Korea., Park MH; Department of Surgery, Chonnam National University Medical School & Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea; mhpark@chonnam.ac.kr. |
| المصدر: | Anticancer research [Anticancer Res] 2024 Aug; Vol. 44 (8), pp. 3493-3500. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens, Greece : Potamitis Press |
| مواضيع طبية MeSH: | Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Breast Neoplasms*/surgery , Lymphatic Metastasis*/pathology , Receptor, ErbB-2*/metabolism , Sentinel Lymph Node*/pathology , Sentinel Lymph Node*/surgery , Sentinel Lymph Node*/metabolism, Humans ; Female ; Middle Aged ; Risk Factors ; Adult ; Retrospective Studies ; Aged ; Lymph Node Excision ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Sentinel Lymph Node Biopsy ; Axilla ; Lymph Nodes/pathology ; Lymph Nodes/surgery |
| مستخلص: | Background/aim: This study aimed to identify the risk factors associated with non-sentinel lymph node (non-SLN) metastasis in case of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer with cN0 on preoperative exam, where the sentinel lymph node (SLN) is positive. Patients and Methods: We conducted a retrospective review of medical records from the Chonnam National University Hwasun Hospital, spanning from January 2013 to January 2020, focusing on patients with HR+, HER2- breast cancer. Specifically, we collected the clinical and pathological data for those patients who underwent axillary lymph node dissection (ALND) due to positive SLN. Results: Among the 166 patients who underwent ALND after positive SLNs, median patient age was 52 years. Univariate analyses demonstrated a significant association between non-SLN metastasis and the number of positive SLNs (p=0.039), SLN positive ratio (p<0.001), and primary tumor size (p=0.018). Multivariate analysis revealed that an SLN ratio >0.55 (p=0.004, HR=3.007, 95% CI=1.427-6.335) was independently associated with non-SLN metastasis. However, neither the number of positive SLN nor primary tumor size showed associations with non-SLN metastases. Conclusion: In patients with HR+, HER2- breast cancer who are cN0, completion of ALND should be considered when the positive SLN ratio is ≥0.55. This approach aims to provide the opportunity for survival benefit through additional adjuvant therapy or to contribute to de-escalation of unnecessary surgery. (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast cancer; non-sentinel lymph node; risk factor; sentinel lymph node biopsy |
| المشرفين على المادة: | EC 2.7.10.1 (Receptor, ErbB-2) EC 2.7.10.1 (ERBB2 protein, human) 0 (Receptors, Estrogen) 0 (Receptors, Progesterone) |
| تواريخ الأحداث: | Date Created: 20240726 Date Completed: 20240727 Latest Revision: 20240730 |
| رمز التحديث: | 20240731 |
| DOI: | 10.21873/anticanres.17169 |
| PMID: | 39060066 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1791-7530 |
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| DOI: | 10.21873/anticanres.17169 |