دورية أكاديمية
Exploitation of porphyrin-based titanium-rich porous organic polymers for targeted phosphopeptide enrichment from the serum of colorectal cancer individuals.
| العنوان: | Exploitation of porphyrin-based titanium-rich porous organic polymers for targeted phosphopeptide enrichment from the serum of colorectal cancer individuals. |
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| المؤلفون: | Wang D; Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Institute of Mass Spectrometry, Ningbo University, Ningbo, 315211, China., Sheng X; Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Institute of Mass Spectrometry, Ningbo University, Ningbo, 315211, China., Shao J; Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Institute of Mass Spectrometry, Ningbo University, Ningbo, 315211, China., Ding CF; Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Institute of Mass Spectrometry, Ningbo University, Ningbo, 315211, China. dingchuanfan@nbu.edu.cn., Yan Y; Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Institute of Mass Spectrometry, Ningbo University, Ningbo, 315211, China. yanyinghua@nbu.edu.cn. |
| المصدر: | Mikrochimica acta [Mikrochim Acta] 2024 Jul 27; Vol. 191 (8), pp. 487. Date of Electronic Publication: 2024 Jul 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wien ; New York : Springer-Verlag. |
| مواضيع طبية MeSH: | Colorectal Neoplasms*/blood , Titanium*/chemistry , Phosphopeptides*/blood , Phosphopeptides*/isolation & purification , Phosphopeptides*/chemistry , Porphyrins*/chemistry, Humans ; Porosity ; Polymers/chemistry |
| مستخلص: | A porphyrin-based titanium-rich porous organic polymer (Th-PPOPs@Ti 4+ ) was designed based on immobilized metal ion affinity chromatography technique and successfully applied to phosphopeptide enrichment with 5,10,15,20-tetrakis(4-carboxyphenyl) porphine tetramethyl ester (TCPTE), 2,3-dihydroxyterephthalaldehyde (DHTA), and 2,3,4-trihydroxybenzaldehyde (THBA) as raw materials. Th-PPOPs@Ti 4+ exhibited remarkable sensitivity (0.5 fmol), high selectivity (β-casein: BSA = 1:2000, molar ratio), outstanding recovery (95.0 ± 1.9%), reusability (10 times), and superior loading capacity (143 mg·g -1 ). In addition, Th-PPOPs@Ti 4+ exhibited excellent ability to specifically capture phosphopeptides from the serum of colorectal cancer (CRC) individuals and normal subjects. Sixty phosphopeptides assigned to 35 phosphoproteins were obtained from the serum of CRC individuals, and 43 phosphopeptides allocated to 28 phosphoproteins were extracted in the serum of healthy individuals via nano-LC-MS/MS. Gene ontology assays revealed that the detected phosphoproteins may be inextricably tied to CRC-associated events, including response to estrogen, inflammatory response, and heparin binding, suggesting that it is possible that these correlative pathways may be implicated in the pathogenesis of CRC. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.) |
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| معلومات مُعتمدة: | 2023YFF0613402 the National K & D program of China |
| فهرسة مساهمة: | Keywords: Analyte enrichment; Colorectal cancer; Nano-LC–MS/MS; Phosphopeptides |
| المشرفين على المادة: | D1JT611TNE (Titanium) 0 (Phosphopeptides) 0 (Porphyrins) 0 (Polymers) |
| تواريخ الأحداث: | Date Created: 20240726 Date Completed: 20240728 Latest Revision: 20240730 |
| رمز التحديث: | 20240730 |
| DOI: | 10.1007/s00604-024-06561-4 |
| PMID: | 39060411 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1436-5073 |
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| DOI: | 10.1007/s00604-024-06561-4 |