دورية أكاديمية
أعرض في EDS

Exploring the Dimensions of Pre-Clinical Research: 3D Cultures as an Investigative Model of Cardiac Fibrosis in Chagas Disease.

التفاصيل البيبلوغرافية
العنوان: Exploring the Dimensions of Pre-Clinical Research: 3D Cultures as an Investigative Model of Cardiac Fibrosis in Chagas Disease.
المؤلفون: Seydel CM; Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil., Gonzaga BMS; Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil., Coelho LL; Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil., Garzoni LR; Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
المصدر: Biomedicines [Biomedicines] 2024 Jun 25; Vol. 12 (7). Date of Electronic Publication: 2024 Jun 25.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: A three-dimensional (3D) cell culture can more precisely mimic tissues architecture and functionality, being a promising alternative model to study disease pathophysiology and drug screening. Chagas disease (CD) is a neglected parasitosis that affects 7 million people worldwide. Trypanosoma cruzi's ( T. cruzi ) mechanisms of invasion/persistence continue to be elucidated. Benznidazole (BZ) and Nifurtimox (NF) are trypanocidal drugs with few effects on the clinical manifestations of the chronic disease. Chronic Chagas cardiomyopathy (CCC) is the main manifestation of CD due to its frequency and severity. The development of fibrosis and hypertrophy in cardiac tissue can lead to heart failure and sudden death. Thus, there is an urgent need for novel therapeutic options. Our group has more than fifteen years of expertise using 3D primary cardiac cell cultures, being the first to reproduce fibrosis and hypertrophy induced by T. cruzi infection in vitro. These primary cardiac spheroids exhibit morphological and functional characteristics that are similar to heart tissue, making them an interesting model for studying CD cardiac fibrosis. Here, we aim to demonstrate that our primary cardiac spheroids are great preclinical models which can be used to develop new insights into CD cardiac fibrosis, presenting advances already achieved in the field, including disease modeling and drug screening.
References: J Cell Physiol. 2015 Jan;230(1):16-26. (PMID: 24912145)
Lancet Infect Dis. 2001 Sep;1(2):92-100. (PMID: 11871482)
Cell. 2016 Jun 16;165(7):1586-1597. (PMID: 27315476)
N Engl J Med. 2015 Jul 30;373(5):456-66. (PMID: 26222561)
Cells. 2019 Dec 12;8(12):. (PMID: 31842346)
Lancet. 2010 Apr 17;375(9723):1388-402. (PMID: 20399979)
Clin Transl Sci. 2021 Sep;14(5):1659-1680. (PMID: 33982436)
Trop Med Infect Dis. 2021 Jul 12;6(3):. (PMID: 34287382)
Curr Opin Immunol. 2017 Oct;48:15-22. (PMID: 28756233)
Int J Cardiol. 2008 Dec 17;131(1):9-17. (PMID: 18692919)
Sci Rep. 2018 May 8;8(1):7239. (PMID: 29740095)
PLoS Negl Trop Dis. 2010 Aug 31;4(8):. (PMID: 20824217)
Cytotherapy. 2011 Sep;13(8):1000-12. (PMID: 21619419)
Mol Biochem Parasitol. 2020 Jul;238:111283. (PMID: 32564978)
J Am Heart Assoc. 2019 Nov 19;8(22):e013365. (PMID: 31718442)
N Engl J Med. 2011 Jun 30;364(26):2527-34. (PMID: 21714649)
Exp Parasitol. 2021 Feb;221:108061. (PMID: 33383023)
J Am Coll Cardiol. 2013 Aug 27;62(9):767-76. (PMID: 23770163)
Front Pharmacol. 2018 Jan 23;9:6. (PMID: 29410625)
J Anat. 2015 Dec;227(6):746-56. (PMID: 25411113)
Front Mol Biosci. 2020 Mar 06;7:33. (PMID: 32211418)
Clin Microbiol Rev. 2011 Jul;24(3):592-630. (PMID: 21734249)
Cardiovasc Res. 2003 Oct 15;60(1):96-107. (PMID: 14522411)
J Travel Med. 2019 Oct 14;26(7):. (PMID: 31407784)
J Infect Dis. 2008 Mar 15;197(6):906-15. (PMID: 18279074)
Arq Bras Cardiol. 2001 Jan;76(1):75-96. (PMID: 11175486)
J Vis Exp. 2017 Mar 27;(121):. (PMID: 28448014)
Lab Chip. 2023 Mar 1;23(5):1080-1096. (PMID: 36628972)
PLoS Negl Trop Dis. 2018 Apr 2;12(4):e0006388. (PMID: 29608569)
Curr Top Microbiol Immunol. 2005;296:89-123. (PMID: 16323421)
Arq Bras Cardiol. 2007 Aug;89(2):119-21, 131-4. (PMID: 17874019)
Infect Dis Clin North Am. 2012 Jun;26(2):275-91. (PMID: 22632639)
Biotechnol Bioeng. 2014 Aug;111(8):1672-85. (PMID: 24615162)
Stem Cells. 2007 Sep;25(9):2224-34. (PMID: 17585171)
Trends Cardiovasc Med. 2017 Feb;27(2):81-91. (PMID: 27622432)
Infect Dis Clin North Am. 2019 Mar;33(1):119-134. (PMID: 30712757)
Infect Immun. 2013 Oct;81(10):3600-8. (PMID: 23856618)
J Infect Dis. 2015 Oct 1;212(7):1160-71. (PMID: 25805753)
Rev Esp Cardiol. 2007 Mar;60(3):285-93. (PMID: 17394874)
Int J Parasitol Drugs Drug Resist. 2020 Apr;12:7-17. (PMID: 31862616)
Acta Trop. 2019 Oct;198:105107. (PMID: 31351074)
Curr Infect Dis Rep. 2012 Jun;14(3):263-74. (PMID: 22477037)
Front Microbiol. 2019 Aug 21;10:1856. (PMID: 31496999)
Parasit Vectors. 2018 Jan 30;11(1):72. (PMID: 29382361)
Exp Cell Res. 2009 Nov 15;315(19):3406-18. (PMID: 19769963)
Pathogens. 2021 Nov 16;10(11):. (PMID: 34832648)
Dis Markers. 2019 Nov 25;2019:3632906. (PMID: 31885735)
Front Cell Infect Microbiol. 2022 Feb 02;11:767576. (PMID: 35186778)
Mem Inst Oswaldo Cruz. 2017 Mar;112(3):224-235. (PMID: 28225900)
Int J Pharm. 2006 Jan 13;307(2):239-43. (PMID: 16293378)
Curr Clin Microbiol Rep. 2018 Mar;5(1):45-54. (PMID: 29868332)
Rev Soc Bras Med Trop. 1986 Jan-Mar;19(1):9-12. (PMID: 3120253)
N Engl J Med. 2006 Aug 24;355(8):799-808. (PMID: 16928995)
J Control Release. 2012 Dec 10;164(2):192-204. (PMID: 22613880)
Sci Rep. 2019 Dec 23;9(1):19717. (PMID: 31873199)
Front Cell Infect Microbiol. 2022 Nov 30;12:1017040. (PMID: 36530434)
N Engl J Med. 2015 Oct;373(14):1295-306. (PMID: 26323937)
Exp Cell Res. 2018 Jan 15;362(2):260-267. (PMID: 29208458)
Expert Opin Investig Drugs. 2014 Sep;23(9):1225-37. (PMID: 24855989)
Biotechnol Adv. 2018 Mar - Apr;36(2):494-505. (PMID: 29408559)
معلومات مُعتمدة: FAPERJ; Oswaldo Cruz Institute; CAPES; CNPq; Brazilian National Congress Parliamentary amendments Nº 13380024 and 13380014
فهرسة مساهمة: Keywords: Chagas disease 3; cardiac spheroids 2; therapy 4; three-dimensional cell culture 1
تواريخ الأحداث: Date Created: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11274318
DOI: 10.3390/biomedicines12071410
PMID: 39061986
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines12071410