دورية أكاديمية
أعرض في EDS

How Transcription Factor Clusters Shape the Transcriptional Landscape.

التفاصيل البيبلوغرافية
العنوان: How Transcription Factor Clusters Shape the Transcriptional Landscape.
المؤلفون: Munshi R; Joseph Henry Laboratories of Physics and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
المصدر: Biomolecules [Biomolecules] 2024 Jul 20; Vol. 14 (7). Date of Electronic Publication: 2024 Jul 20.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2011-
مواضيع طبية MeSH: Transcription Factors*/metabolism , Transcription Factors*/genetics , Transcription, Genetic* , Chromatin*/metabolism , Chromatin*/genetics , Promoter Regions, Genetic*, Humans ; Animals
مستخلص: In eukaryotic cells, gene transcription typically occurs in discrete periods of promoter activity, interspersed with intervals of inactivity. This pattern deviates from simple stochastic events and warrants a closer examination of the molecular interactions that activate the promoter. Recent studies have identified transcription factor (TF) clusters as key precursors to transcriptional bursting. Often, these TF clusters form at chromatin segments that are physically distant from the promoter, making changes in chromatin conformation crucial for promoter-TF cluster interactions. In this review, I explore the formation and constituents of TF clusters, examining how the dynamic interplay between chromatin architecture and TF clustering influences transcriptional bursting. Additionally, I discuss techniques for visualizing TF clusters and provide an outlook on understanding the remaining gaps in this field.
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معلومات مُعتمدة: PHY-1734030 National Science Foundation
فهرسة مساهمة: Keywords: biomolecular condensates; clusters; gene regulation; microscopy; transcription; transcription factor
المشرفين على المادة: 0 (Transcription Factors)
0 (Chromatin)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11274464
DOI: 10.3390/biom14070875
PMID: 39062589
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-273X
DOI:10.3390/biom14070875