دورية أكاديمية
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Chronic Adolescent Restraint Stress Downregulates miRNA-200a Expression in Male and Female C57BL/6J and BALB/cJ Mice.

التفاصيل البيبلوغرافية
العنوان: Chronic Adolescent Restraint Stress Downregulates miRNA-200a Expression in Male and Female C57BL/6J and BALB/cJ Mice.
المؤلفون: Kamens HM; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16801, USA., Anziano EK; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16801, USA., Horton WJ; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16801, USA., Cavigelli SA; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16801, USA.
المصدر: Genes [Genes (Basel)] 2024 Jul 03; Vol. 15 (7). Date of Electronic Publication: 2024 Jul 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: MicroRNAs*/genetics , Mice, Inbred C57BL* , Stress, Psychological*/genetics , Restraint, Physical*, Animals ; Female ; Male ; Mice ; Mice, Inbred BALB C ; Down-Regulation ; Hippocampus/metabolism ; Corticosterone/blood
مستخلص: Adolescence is a critical developmental period when the brain is plastic, and stress exposure can have lasting physiological consequences. One mechanism through which adolescent stress may have lasting effects is by altering microRNAs (miRNAs), leading to wide-scale gene expression changes. Three prior independent studies used unbiased approaches (RNA sequencing or microarray) to identify miRNAs differentially expressed by chronic variable stress in male rodents. In all three studies, miRNA-200a was differentially expressed in areas of the brain associated with emotion regulation. The current study extends this research to determine if chronic non-variable adolescent stress downregulates miRNA-200a expression by looking at two strains (BALB/cJ and C57BL/6J) of male and female mice. We utilized a 14-day (2 h/day) restraint stress protocol and verified stress effects on adolescent body weight gain and circulating corticosterone concentrations relative to non-restraint controls. Mice were then left undisturbed until they were euthanized in adulthood, at which time brains were collected to measure miRNA-200a in the ventral hippocampus. Three weeks after adolescent stress ended, differences in body weight between groups were no longer significant; however, animals exposed to stress had less miRNA-200a expression in the ventral hippocampus than control animals. These data implicate miRNA-200a expression as a potential mechanism by which adolescent stress can have persistent impacts on multiple outcomes in both male and female mice.
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معلومات مُعتمدة: N/A The Pennsylvania State University Consortium on Substance Use and Addiction; N/A The Pennsylvania State University Social Science Research Institute
فهرسة مساهمة: Keywords: adolescent stress; miR-200a; microRNA; microRNA-200a
المشرفين على المادة: 0 (MicroRNAs)
0 (Mirn200 microRNA, mouse)
W980KJ009P (Corticosterone)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11275362
DOI: 10.3390/genes15070873
PMID: 39062652
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes15070873