دورية أكاديمية
أعرض في EDS

Genetic Ancestry and Self-Reported "Skin Color/Race" in the Urban Admixed Population of São Paulo City, Brazil.

التفاصيل البيبلوغرافية
العنوان: Genetic Ancestry and Self-Reported "Skin Color/Race" in the Urban Admixed Population of São Paulo City, Brazil.
المؤلفون: Pereira JL; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil., de Souza CA; Department of Statistics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo 05508-090, Brazil., Neyra JEM; Department of Statistics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo 05508-090, Brazil., Leite JMRS; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil., Cerqueira A; Department of Statistics, Federal University of Sao Carlos, São Carlos 13565-905, Brazil., Mingroni-Netto RC; Human Genome and Stem Cell Research Center, Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo 05508-090, Brazil., Soler JMP; Department of Statistics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo 05508-090, Brazil., Rogero MM; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil., Sarti FM; School of Arts, Sciences and Humanities, University of Sao Paulo, São Paulo 03828-000, Brazil., Fisberg RM; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil.
المصدر: Genes [Genes (Basel)] 2024 Jul 13; Vol. 15 (7). Date of Electronic Publication: 2024 Jul 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Skin Pigmentation*/genetics , Polymorphism, Single Nucleotide* , Self Report*, Humans ; Brazil ; Male ; Female ; Adult ; White People/genetics ; Urban Population ; Black People/genetics ; Racial Groups/genetics ; Middle Aged ; Genetics, Population
مستخلص: Epidemiological studies frequently classify groups based on phenotypes like self-reported skin color/race, which inaccurately represent genetic ancestry and may lead to misclassification, particularly among individuals of multiracial backgrounds. This study aimed to characterize both global and local genome-wide genetic ancestries and to assess their relationship with self-reported skin color/race in an admixed population of Sao Paulo city. We analyzed 226,346 single-nucleotide polymorphisms from 841 individuals participating in the population-based ISA-Nutrition study. Our findings confirmed the admixed nature of the population, demonstrating substantial European, significant Sub-Saharan African, and minor Native American ancestries, irrespective of skin color. A correlation was observed between global genetic ancestry and self-reported color-race, which was more evident in the extreme proportions of African and European ancestries. Individuals with higher African ancestry tended to identify as Black, those with higher European ancestry tended to identify as White, and individuals with higher Native American ancestry were more likely to self-identify as Mixed, a group with diverse ancestral compositions. However, at the individual level, this correlation was notably weak, and no deviations were observed for specific regions throughout the individual's genome. Our findings emphasize the significance of accurately defining and thoroughly analyzing race and ancestry, especially within admixed populations.
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معلومات مُعتمدة: 2012/22113-9; 2017/05125-7; 2019/23985-9 Fundação de Amparo à Pesquisa do Estado de São Paulo; 472873/2012-1 National Council for Scientific and Technological Development; 2013-0.235.936-0 São Paulo Municipal Health Department
فهرسة مساهمة: Keywords: Brazilian population; ancestry markers; diversity; ethnicity; genome-wide analysis; genomics; health survey; human population genetics; multi-ancestry; racial identity; single-nucleotide polymorphisms (SNPs)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11276533
DOI: 10.3390/genes15070917
PMID: 39062696
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes15070917