دورية أكاديمية
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Effects of Age and MPTP-Induced Parkinson's Disease on the Expression of Genes Associated with the Regulation of the Sleep-Wake Cycle in Mice.

التفاصيل البيبلوغرافية
العنوان: Effects of Age and MPTP-Induced Parkinson's Disease on the Expression of Genes Associated with the Regulation of the Sleep-Wake Cycle in Mice.
المؤلفون: Semenova EI; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Rudenok MM; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Rybolovlev IN; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Shulskaya MV; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Lukashevich MV; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Partevian SA; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Budko AI; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Nesterov MS; Scientific Center for Biomedical Technologies of the Federal Biomedical Agency of Russia, 119435 Krasnogorsk, Russia., Abaimov DA; Research Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia., Slominsky PA; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Shadrina MI; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia., Alieva AK; National Research Centre 'Kurchatov Institute', 2 Kurchatova Sq., 123182 Moscow, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 14; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Circadian Rhythm*/genetics, Animals ; Mice ; Male ; Gene Expression Regulation ; Mice, Inbred C57BL ; Sleep/genetics ; Aging/genetics ; Disease Models, Animal ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Substantia Nigra/metabolism ; Corpus Striatum/metabolism ; MPTP Poisoning/genetics ; MPTP Poisoning/metabolism ; Age Factors ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Wakefulness
مستخلص: Parkinson's disease (PD) is characterized by a long prodromal period, during which patients often have sleep disturbances. The histaminergic system and circadian rhythms play an important role in the regulation of the sleep-wake cycle. Changes in the functioning of these systems may be involved in the pathogenesis of early stages of PD and may be age-dependent. Here, we have analyzed changes in the expression of genes associated with the regulation of the sleep-wake cycle ( Hnmt , Hrh1 , Hrh3 , Per1 , Per2 , and Chrm3 ) in the substantia nigra (SN) and striatum of normal male mice of different ages, as well as in young and adult male mice with an MPTP-induced model of the early symptomatic stage (ESS) of PD. Age-dependent expression analysis in normal mouse brain tissue revealed changes in Hrh3 , Per1 , Per2 , and Chrm3 genes in adult mice relative to young mice. When gene expression was examined in mice with the MPTP-induced model of the ESS of PD, changes in the expression of all studied genes were found only in the SN of adult mice with the ESS model of PD. These data suggest that age is a significant factor influencing changes in the expression of genes associated with sleep-wake cycle regulation in the development of PD.
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معلومات مُعتمدة: 20-15-00262 Russian Science Foundation; GZ-5F-IMG.9 National Research Center "Kurchatov Institute"
فهرسة مساهمة: Keywords: MPTP model; Parkinson’s disease; circadian genes; gene expression; histamine; neurodegeneration; sleep–wake cycle; transcriptome
المشرفين على المادة: 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11276692
DOI: 10.3390/ijms25147721
PMID: 39062963
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25147721