دورية أكاديمية
أعرض في EDS

Therapeutic Efficacy of an Erythromycin-Loaded Coaxial Nanofiber Coating in a Rat Model of S. aureus -Induced Periprosthetic Joint Infection.

التفاصيل البيبلوغرافية
العنوان: Therapeutic Efficacy of an Erythromycin-Loaded Coaxial Nanofiber Coating in a Rat Model of S. aureus -Induced Periprosthetic Joint Infection.
المؤلفون: Markel DC; The CORE Institute, 26750 Providence Pkwy #200, Novi, MI 48374, USA.; Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, MI 48201, USA.; Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA., Powell D; Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA., Wu B; Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA., Pawlitz P; Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA., Bou-Akl T; Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA., Chen L; Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, MI 48201, USA., Shi T; Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, MI 48201, USA., Ren W; Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA.; John D. Dingell VA Medical Center, 4646 John R St., Detroit, MI 48201, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 19; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Nanofibers*/chemistry , Prosthesis-Related Infections*/drug therapy , Prosthesis-Related Infections*/microbiology , Erythromycin*/pharmacology , Erythromycin*/administration & dosage , Coated Materials, Biocompatible*/pharmacology , Coated Materials, Biocompatible*/chemistry , Staphylococcal Infections*/drug therapy , Staphylococcal Infections*/microbiology , Staphylococcus aureus*/drug effects , Disease Models, Animal*, Animals ; Rats ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/administration & dosage ; Male ; Titanium/chemistry ; Titanium/pharmacology ; X-Ray Microtomography ; Rats, Sprague-Dawley
مستخلص: Implant surface nanofiber (NF) coatings represent an alternative way to prevent/treat periprosthetic joint infection (PJI) via local drug release. We developed and characterized a coaxial erythromycin (EM)-doped PLGA/PCL-PVA NF coating. The purpose of this study was to determine the efficacy of EM-NF coatings (EM0, no EM, EM100 (100 mg/mL), and EM1000 (1000 mg/mL) wt/wt) in a rat PJI model. A strong bond of the EM-NF coating to the surface of titanium (Ti) pins was confirmed by in vitro mechanical testing. Micro-computed tomography (mCT) analysis showed that both EM100 and EM1000 NF effectively reduced periprosthetic osteolysis compared to EM0 at 8 and 16 weeks after implantation. Histology showed that EM100 and EM1000 coatings effectively controlled infection and enhanced periprosthetic new bone formation. The bone implant contact (BIC) of EM100 (35.08%) was higher than negative controls and EM0 (3.43% and 0%, respectively). The bone area fraction occupancy (BAFO) of EM100 (0.63 mm 2 ) was greater than controls and EM0 (0.390 mm 2 and 0.0 mm 2 , respectively). The BAFO of EM100 was higher than that of EM1000 (0.3 mm 2 ). These findings may provide a basis for a new implant surface fabrication strategy aimed at reducing the risks of defective osseointegration and PJI.
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معلومات مُعتمدة: RX001818-01 United States VA VA
فهرسة مساهمة: Keywords: coaxial nanofibers; drug release; erythromycin (EM); osteointegration; periprosthetic joint infection (PJI); rat model; surface coating
المشرفين على المادة: 63937KV33D (Erythromycin)
0 (Coated Materials, Biocompatible)
0 (Anti-Bacterial Agents)
D1JT611TNE (Titanium)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11276967
DOI: 10.3390/ijms25147926
PMID: 39063169
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25147926