دورية أكاديمية
أعرض في EDS

The Role of Neutrophyl-to-Lymphocyte Ratio as a Predictor of Ovarian Torsion in Children: Results of a Multicentric Study.

التفاصيل البيبلوغرافية
العنوان: The Role of Neutrophyl-to-Lymphocyte Ratio as a Predictor of Ovarian Torsion in Children: Results of a Multicentric Study.
المؤلفون: Delgado-Miguel C; Pediatric Surgery Department, Fundación Jiménez Díaz University Hospital, Avenida de los Reyes Católicos, 2, 28040 Madrid, Spain.; Institute for Health Research IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain., Arredondo-Montero J; Pediatric Surgery Department, Complejo Asistencial Universitario de León, 24071 Castilla y León, Spain., Moreno-Alfonso JC; Pediatric Surgery Department, Navarra University Hospital, 31008 Pamplona, Spain., San Basilio M; Pediatric Surgery Department, La Paz University Hospital, 28046 Madrid, Spain., Peña Pérez R; Pediatric Surgery Department, Rey Juan Carlos University Hospital, 28933 Móstoles, Spain., Carrera N; Pediatric Surgery Department, Toledo University Hospital, 45005 Toledo, Spain., Aguado P; Pediatric Surgery Department, Fundación Jiménez Díaz University Hospital, Avenida de los Reyes Católicos, 2, 28040 Madrid, Spain., Fuentes E; Pediatric Surgery Department, Fundación Jiménez Díaz University Hospital, Avenida de los Reyes Católicos, 2, 28040 Madrid, Spain.; Pediatric Surgery Department, Rey Juan Carlos University Hospital, 28933 Móstoles, Spain.; Pediatric Surgery Department, Villalba University Hospital, 28400 Villalba, Spain., Díez R; Pediatric Surgery Department, Fundación Jiménez Díaz University Hospital, Avenida de los Reyes Católicos, 2, 28040 Madrid, Spain.; Pediatric Surgery Department, Rey Juan Carlos University Hospital, 28933 Móstoles, Spain.; Pediatric Surgery Department, Villalba University Hospital, 28400 Villalba, Spain., Hernández-Oliveros F; Institute for Health Research IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Pediatric Surgery Department, La Paz University Hospital, 28046 Madrid, Spain.
المصدر: Life (Basel, Switzerland) [Life (Basel)] 2024 Jul 18; Vol. 14 (7). Date of Electronic Publication: 2024 Jul 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Introduction: Pediatric ovarian torsion (OT) is an emergency condition that remains challenging to diagnose because of its overall unspecific clinical presentation. The aim of this study was to determine the diagnostic value of clinical, ultrasound, and inflammatory laboratory markers in pediatric OT.
Methods: We performed a retrospective multicentric case-control study in patients with clinical and ultrasound suspicion of OT, in whom surgical examination was performed between 2016-2022 in seven pediatric hospitals. Patients were divided into two groups according to intraoperative findings: OT group (ovarian torsion), defined as torsion of the ovarian axis at least 360°, and non-OT group (no torsion). Demographics, clinical, ultrasound, and laboratory features at admission were analyzed. The diagnostic yield analysis was performed using logistic regression models, and the results were represented by ROC curves.
Results: We included a total of 110 patients (75 in OT group; 35 in non-OT group), with no demographic or clinical differences between them. OT-group patients had shorter time from symptom onset (8 vs. 12 h; p = 0.023), higher ultrasound median ovarian volume (63 vs. 51 mL; p = 0.013), and a significant increase in inflammatory markers (leukocytes, neutrophils, neutrophil-to-lymphocyte ratio, C-reactive protein) when compared to the non-OT group. In the ROC curve analysis, the neutrophil-to-lymphocyte ratio (NLR) presented the highest AUC (0.918), with maximum sensitivity (92.4%) and specificity (90.1%) at the cut-off point NLR = 2.57.
Conclusions: NLR can be considered as a useful predictor of pediatric OT in cases with clinical and ultrasound suspicion. Values above 2.57 may help to anticipate urgent surgical treatment in these patients.
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فهرسة مساهمة: Keywords: children; neutrophil-to-lymphocyte ratio; ovarian torsion; predictive factors
تواريخ الأحداث: Date Created: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11277755
DOI: 10.3390/life14070889
PMID: 39063642
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-1729
DOI:10.3390/life14070889