دورية أكاديمية
Effects of Heat-Treated Lactobacillus helveticus CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial.
العنوان: | Effects of Heat-Treated Lactobacillus helveticus CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial. |
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المؤلفون: | Tanihiro R; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Yuki M; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Sakano K; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Sasai M; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Sawada D; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Ebihara S; Chiyoda Paramedical Care Clinic, Tokyo 101-0047, Japan., Hirota T; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan. |
المصدر: | Nutrients [Nutrients] 2024 Jul 10; Vol. 16 (14). Date of Electronic Publication: 2024 Jul 10. |
نوع المنشور: | Journal Article; Randomized Controlled Trial |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI Publishing |
مواضيع طبية MeSH: | Lactobacillus helveticus* , Gastrointestinal Microbiome* , Probiotics*/administration & dosage , Hot Temperature* , Feces*/microbiology , Constipation*/microbiology , Constipation*/therapy , Cultured Milk Products*/microbiology, Humans ; Double-Blind Method ; Adult ; Female ; Male ; Middle Aged ; Young Adult ; Animals ; Milk/microbiology ; Fermentation |
مستخلص: | Probiotic-fermented milk is commonly used to maintain intestinal health. However, the effects of heat-treated fermented milk, which does not contain live microorganisms, on intestinal function are not yet fully understood. This study aimed to investigate whether heat-treated Lactobacillus helveticus CP790-fermented milk affects fecal microbiota and gut health as a "postbiotic". A randomized, double-blind, placebo-controlled trial was conducted in healthy Japanese individuals aged 20-59 years with a tendency toward constipation. Participants consumed 100 mL of either the test beverage ( n = 60) or placebo beverage ( n = 60) for four weeks. The test beverages were prepared with heat-treated CP790-fermented milk, while the placebo beverages were prepared with nonfermented milk flavored with lactic acid. Fecal samples were analyzed using 16S rRNA gene sequencing. Constipation symptoms were assessed using defecation logs and the Patient Assessment of Constipation Symptoms (PAC-SYM) questionnaire. Mood state was also assessed using the Profile of Mood States 2 (POMS2) questionnaire to explore its potential as a "psychobiotic". Desulfobacterota were significantly decreased by CP790-fermented milk intake. PICRUSt2 analysis predicted a decrease in the proportion of genes involved in the sulfate reduction pathway following the consumption of CP790-fermented milk. The CP790-fermented milk intervention significantly improved stool consistency and straining during defecation. These improvements were correlated with a decrease in Desulfobacterota . After the intervention, overall mood, expressed as total mood disturbance, and depression-dejection were significantly better in the CP790 group than in the placebo group. These results suggest that the intake of CP790-fermented milk could be effective in modulating gut microbiota and improving constipation symptoms and mood states. |
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معلومات مُعتمدة: | AQI88108 Asahi Group Holdings, Ltd., Japan. |
فهرسة مساهمة: | Keywords: Lactobacillus helveticus; constipation; gut microbiota; mood state; postbiotic |
تواريخ الأحداث: | Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729 |
رمز التحديث: | 20240729 |
مُعرف محوري في PubMed: | PMC11280423 |
DOI: | 10.3390/nu16142191 |
PMID: | 39064634 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6643 |
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DOI: | 10.3390/nu16142191 |