دورية أكاديمية
أعرض في EDS

Effects of Heat-Treated Lactobacillus helveticus CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial.

التفاصيل البيبلوغرافية
العنوان: Effects of Heat-Treated Lactobacillus helveticus CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial.
المؤلفون: Tanihiro R; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Yuki M; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Sakano K; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Sasai M; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Sawada D; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan., Ebihara S; Chiyoda Paramedical Care Clinic, Tokyo 101-0047, Japan., Hirota T; Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Moriya 302-0106, Japan.
المصدر: Nutrients [Nutrients] 2024 Jul 10; Vol. 16 (14). Date of Electronic Publication: 2024 Jul 10.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Lactobacillus helveticus* , Gastrointestinal Microbiome* , Probiotics*/administration & dosage , Hot Temperature* , Feces*/microbiology , Constipation*/microbiology , Constipation*/therapy , Cultured Milk Products*/microbiology, Humans ; Double-Blind Method ; Adult ; Female ; Male ; Middle Aged ; Young Adult ; Animals ; Milk/microbiology ; Fermentation
مستخلص: Probiotic-fermented milk is commonly used to maintain intestinal health. However, the effects of heat-treated fermented milk, which does not contain live microorganisms, on intestinal function are not yet fully understood. This study aimed to investigate whether heat-treated Lactobacillus helveticus CP790-fermented milk affects fecal microbiota and gut health as a "postbiotic". A randomized, double-blind, placebo-controlled trial was conducted in healthy Japanese individuals aged 20-59 years with a tendency toward constipation. Participants consumed 100 mL of either the test beverage ( n = 60) or placebo beverage ( n = 60) for four weeks. The test beverages were prepared with heat-treated CP790-fermented milk, while the placebo beverages were prepared with nonfermented milk flavored with lactic acid. Fecal samples were analyzed using 16S rRNA gene sequencing. Constipation symptoms were assessed using defecation logs and the Patient Assessment of Constipation Symptoms (PAC-SYM) questionnaire. Mood state was also assessed using the Profile of Mood States 2 (POMS2) questionnaire to explore its potential as a "psychobiotic". Desulfobacterota were significantly decreased by CP790-fermented milk intake. PICRUSt2 analysis predicted a decrease in the proportion of genes involved in the sulfate reduction pathway following the consumption of CP790-fermented milk. The CP790-fermented milk intervention significantly improved stool consistency and straining during defecation. These improvements were correlated with a decrease in Desulfobacterota . After the intervention, overall mood, expressed as total mood disturbance, and depression-dejection were significantly better in the CP790 group than in the placebo group. These results suggest that the intake of CP790-fermented milk could be effective in modulating gut microbiota and improving constipation symptoms and mood states.
References: J Gastroenterol Hepatol. 2021 Jun;36(6):1529-1537. (PMID: 33047825)
Eur J Nutr. 2017 Feb;56(1):45-53. (PMID: 26419583)
J Sci Food Agric. 2017 Jun;97(8):2382-2391. (PMID: 27664398)
Gut Microbes. 2023 Jan-Dec;15(1):2157697. (PMID: 36573834)
Microorganisms. 2021 May 10;9(5):. (PMID: 34068832)
Qual Life Res. 2015 Jul;24(7):1597-605. (PMID: 25522976)
Microb Ecol Health Dis. 2015 Feb 02;26:26191. (PMID: 25651997)
Biol Psychiatry. 2013 Nov 15;74(10):720-6. (PMID: 23759244)
Am J Clin Nutr. 2014 Oct;100(4):1075-84. (PMID: 25099542)
Benef Microbes. 2018 Dec 7;9(6):855-864. (PMID: 30099891)
Appl Environ Microbiol. 2016 May 31;82(12):3649-58. (PMID: 27208120)
J Dairy Sci. 2005 Feb;88(2):527-33. (PMID: 15653517)
Gut. 2009 Jun;58(6):751-61. (PMID: 18852258)
Nutrients. 2019 Aug 10;11(8):. (PMID: 31405122)
J Epidemiol. 2012;22(2):151-9. (PMID: 22343326)
Nutrients. 2017 Jun 27;9(7):. (PMID: 28654019)
Int J Food Microbiol. 2009 Jan 15;128(3):429-34. (PMID: 18977549)
Lancet. 2020 Nov 21;396(10263):1664-1674. (PMID: 33049221)
BMC Microbiol. 2020 Nov 25;20(1):361. (PMID: 33238885)
Aliment Pharmacol Ther. 2007 Mar 1;25(5):599-608. (PMID: 17305761)
Int J Syst Evol Microbiol. 2020 Nov;70(11):5972-6016. (PMID: 33151140)
Int J Mol Sci. 2023 Jul 20;24(14):. (PMID: 37511464)
BMC Immunol. 2017 Jan 6;18(1):2. (PMID: 28061847)
J Adv Res. 2020 Mar 17;27:55-69. (PMID: 33318866)
Am J Gastroenterol. 2011 Sep;106(9):1582-91; quiz 1581, 1592. (PMID: 21606976)
J Dairy Sci. 2018 Jun;101(6):4830-4841. (PMID: 29573807)
BMJ. 1990 Feb 17;300(6722):439-40. (PMID: 2107897)
J Psychosom Res. 2007 Oct;63(4):441-9. (PMID: 17905054)
Sci Rep. 2017 Jan 12;7:40227. (PMID: 28079151)
Trends Neurosci. 2016 Nov;39(11):763-781. (PMID: 27793434)
Front Immunol. 2023 Jun 08;14:1181973. (PMID: 37359525)
Curr Gastroenterol Rep. 2015 Dec;17(12):47. (PMID: 26449614)
Mol Pain. 2015 May 02;11:24. (PMID: 25934637)
J Pers Assess. 1983 Jun;47(3):305-6. (PMID: 6886962)
Benef Microbes. 2023 Apr 18;14(2):109-118. (PMID: 37026368)
J Biochem. 1993 Nov;114(5):740-5. (PMID: 8113230)
Behav Res Methods. 2007 May;39(2):175-91. (PMID: 17695343)
Curr Opin Neurobiol. 2020 Jun;62:102-114. (PMID: 32163822)
Front Physiol. 2012 Nov 28;3:448. (PMID: 23226130)
J Abnorm Psychol. 1964 Dec;69:620-7. (PMID: 14241709)
Foods. 2022 Apr 08;11(8):. (PMID: 35454664)
Nat Biotechnol. 2013 Sep;31(9):814-21. (PMID: 23975157)
Nutrients. 2023 Nov 08;15(22):. (PMID: 38004120)
Antioxidants (Basel). 2023 Aug 06;12(8):. (PMID: 37627565)
Nutr Neurosci. 2024 Jun;27(6):607-619. (PMID: 37496309)
Biosci Microbiota Food Health. 2018;37(3):59-65. (PMID: 30094121)
J Am Chem Soc. 2011 Nov 16;133(45):18003-5. (PMID: 21999237)
J Dairy Sci. 1994 Apr;77(4):917-22. (PMID: 8201050)
J Pharmacol Sci. 2012;119(3):293-6. (PMID: 22785020)
Microorganisms. 2023 Jul 07;11(7):. (PMID: 37512944)
معلومات مُعتمدة: AQI88108 Asahi Group Holdings, Ltd., Japan.
فهرسة مساهمة: Keywords: Lactobacillus helveticus; constipation; gut microbiota; mood state; postbiotic
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11280423
DOI: 10.3390/nu16142191
PMID: 39064634
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16142191