دورية أكاديمية
أعرض في EDS

Plant-Produced Chimeric Hepatitis E Virus-like Particles as Carriers for Antigen Presentation.

التفاصيل البيبلوغرافية
العنوان: Plant-Produced Chimeric Hepatitis E Virus-like Particles as Carriers for Antigen Presentation.
المؤلفون: Mardanova ES; Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia., Vasyagin EA; Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia., Kotova KG; Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia., Zahmanova GG; Department of Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria.; Department of Technology Transfer and IP Management, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria., Ravin NV; Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.
المصدر: Viruses [Viruses] 2024 Jul 08; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Hepatitis E virus*/immunology , Hepatitis E virus*/genetics , Nicotiana*/virology , Nicotiana*/genetics , Capsid Proteins*/genetics , Capsid Proteins*/immunology , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/immunology , Antigen Presentation* , Viral Matrix Proteins*/genetics , Viral Matrix Proteins*/immunology, Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Vaccines, Virus-Like Particle/immunology ; Vaccines, Virus-Like Particle/genetics ; Plants, Genetically Modified ; Influenza A virus/immunology ; Influenza A virus/genetics ; Hepatitis E/immunology ; Hepatitis E/prevention & control ; Hepatitis E/virology ; Viroporin Proteins
مستخلص: A wide range of virus-like particles (VLPs) is extensively employed as carriers to display various antigens for vaccine development to fight against different infections. The plant-produced truncated variant of the hepatitis E virus (HEV) coat protein is capable of forming VLPs. In this study, we demonstrated that recombinant fusion proteins comprising truncated HEV coat protein with green fluorescent protein (GFP) or four tandem copies of the extracellular domain of matrix protein 2 (M2e) of influenza A virus inserted at the Tyr485 position could be efficiently expressed in Nicotiana benthamiana plants using self-replicating vector based on the potato virus X genome. The plant-produced fusion proteins in vivo formed VLPs displaying GFP and 4M2e. Therefore, HEV coat protein can be used as a VLP carrier platform for the presentation of relatively large antigens comprising dozens to hundreds of amino acids. Furthermore, plant-produced HEV particles could be useful research tools for the development of recombinant vaccines against influenza.
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معلومات مُعتمدة: 075-15-2022-318 Ministry of Science and Higher Education of the Russian Federation; BG05M2OP001-1.003-001-C01 Bulgarian "Science and Education for Smart Growth" Operational Program
فهرسة مساهمة: Keywords: M2e peptide; Nicotiana benthamiana; hepatitis E virus; influenza; transient expression; vaccine; viral vector; virus-like particle
المشرفين على المادة: 0 (Capsid Proteins)
0 (Recombinant Fusion Proteins)
0 (Viral Matrix Proteins)
147336-22-9 (Green Fluorescent Proteins)
0 (Vaccines, Virus-Like Particle)
0 (M2 protein, Influenza A virus)
0 (Viroporin Proteins)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11281382
DOI: 10.3390/v16071093
PMID: 39066255
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v16071093