دورية أكاديمية
Increase of Synergistic Secondary Antiviral Mutations in the Evolution of A(H1N1)pdm09 Influenza Virus Neuraminidases.
العنوان: | Increase of Synergistic Secondary Antiviral Mutations in the Evolution of A(H1N1)pdm09 Influenza Virus Neuraminidases. |
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المؤلفون: | Duwe SC; Unit 17 Influenza and Other Respiratory Viruses, Department 1 Infectious Diseases, Robert Koch-Institute, 13353 Berlin, Germany., Milde J; Unit 17 Influenza and Other Respiratory Viruses, Department 1 Infectious Diseases, Robert Koch-Institute, 13353 Berlin, Germany., Heider A; Unit 17 Influenza and Other Respiratory Viruses, Department 1 Infectious Diseases, Robert Koch-Institute, 13353 Berlin, Germany., Wedde M; Unit 17 Influenza and Other Respiratory Viruses, Department 1 Infectious Diseases, Robert Koch-Institute, 13353 Berlin, Germany., Schweiger B; Unit 17 Influenza and Other Respiratory Viruses, Department 1 Infectious Diseases, Robert Koch-Institute, 13353 Berlin, Germany., Dürrwald R; Unit 17 Influenza and Other Respiratory Viruses, Department 1 Infectious Diseases, Robert Koch-Institute, 13353 Berlin, Germany. |
المصدر: | Viruses [Viruses] 2024 Jul 11; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مواضيع طبية MeSH: | Neuraminidase*/genetics , Influenza A Virus, H1N1 Subtype*/genetics , Influenza A Virus, H1N1 Subtype*/drug effects , Influenza A Virus, H1N1 Subtype*/enzymology , Antiviral Agents*/pharmacology , Drug Resistance, Viral*/genetics , Influenza, Human*/virology , Phylogeny* , Evolution, Molecular* , Viral Proteins*/genetics , Viral Proteins*/metabolism , Oseltamivir*/pharmacology , Mutation*, Humans ; Germany ; Amino Acid Substitution ; Animals ; Dogs |
مستخلص: | The unexpected emergence of oseltamivir-resistant A(H1N1) viruses in 2008 was facilitated in part by the establishment of permissive secondary neuraminidase (NA) substitutions that compensated for the fitness loss due to the NA-H275Y resistance substitution. These viruses were replaced in 2009 by oseltamivir-susceptible A(H1N1)pdm09 influenza viruses. Genetic analysis and screening of A(H1N1)pdm09 viruses circulating in Germany between 2009 and 2024 were conducted to identify any potentially synergistic or resistance-associated NA substitutions. Selected viruses were then subjected to further characterization in vitro. In the NA gene of circulating A(H1N1)pdm09 viruses, two secondary substitutions, NA-V241I and NA-N369K, were identified. These substitutions demonstrated a stable lineage in phylogenetic analysis since the 2010-2011 influenza season. The data indicate a slight increase in viral NA bearing two additional potentially synergistic substitutions, NA-I223V and NA-S247N, in the 2023-2024 season, which both result in a slight reduction in susceptibility to NA inhibitors. The accumulation of secondary synergistic substitutions in the NA of A(H1N1)pdm09 viruses increases the probability of the emergence of antiviral-resistant viruses. Therefore, it is crucial to closely monitor the evolution of circulating influenza viruses and to develop additional antiviral drugs against different target proteins. |
References: | Lancet Reg Health Eur. 2021 Jul;6:100112. (PMID: 34124707) Viruses. 2018 Jun 21;10(7):. (PMID: 29933553) J Med Virol. 2021 Aug;93(8):4638-4646. (PMID: 33792930) J Health Monit. 2023 Jun 14;8(2):20-38. (PMID: 37408711) J Virol. 2014 Feb;88(3):1652-8. (PMID: 24257597) PLoS Pathog. 2011 Oct;7(10):e1002249. (PMID: 22028647) GMS Infect Dis. 2021 Apr 30;9:Doc02. (PMID: 34113534) Science. 2010 Jun 4;328(5983):1272-5. (PMID: 20522774) Virus Res. 2023 Sep;334:199182. (PMID: 37490957) Antiviral Res. 2018 Sep;157:38-46. (PMID: 29981793) J Virol Methods. 2008 Nov;153(2):134-41. (PMID: 18725246) Med Microbiol Immunol. 2012 Feb;201(1):61-72. (PMID: 21688167) Curr Opin Virol. 2014 Oct;8:22-9. (PMID: 24866471) Vaccines (Basel). 2021 Jun 03;9(6):. (PMID: 34205119) PLoS One. 2010 Apr 01;5(4):e9966. (PMID: 20376359) J Med Virol. 2015 Jan;87(1):45-56. (PMID: 25042157) Antimicrob Agents Chemother. 2012 Mar;56(3):1208-14. (PMID: 22203589) J Virol. 2022 Aug 10;96(15):e0091822. (PMID: 35867563) Antiviral Res. 2011 Jan;89(1):115-8. (PMID: 21070812) Lancet Microbe. 2024 Jul;5(7):627-628. (PMID: 38493791) Nat Struct Mol Biol. 2010 Oct;17(10):1266-8. (PMID: 20852645) Nat Commun. 2014 Oct 09;5:5029. (PMID: 25297528) Science. 2009 Jul 10;325(5937):197-201. (PMID: 19465683) Clin Infect Dis. 2010 Oct 15;51(8):983-4. (PMID: 20858074) Infect Drug Resist. 2023 Feb 15;16:949-959. (PMID: 36814825) Emerg Infect Dis. 2010 Jun;16(6):926-35. (PMID: 20507742) Euro Surveill. 2011 Jun 09;16(23):. (PMID: 21679678) Pediatr Infect Dis J. 2004 Nov;23(11 Suppl):S262-9. (PMID: 15577582) Trop Med Infect Dis. 2019 Apr 18;4(2):. (PMID: 31003518) Science. 2010 Jun 4;328(5983):1243-4. (PMID: 20522766) Virus Res. 2022 Dec;322:198926. (PMID: 36096395) J Virol. 2003 Aug;77(15):8418-25. (PMID: 12857911) Antiviral Res. 2024 Jul;227:105918. (PMID: 38795911) Int J Med Microbiol. 2024 Mar;314:151598. (PMID: 38237287) Antiviral Res. 2009 Apr;82(1):34-41. (PMID: 19428593) Wkly Epidemiol Rec. 2012 Sep 28;87(39):369-74. (PMID: 23061103) PLoS Pathog. 2014 Apr 03;10(4):e1004065. (PMID: 24699865) Antiviral Res. 2016 Aug;132:178-85. (PMID: 27265623) Antiviral Res. 2022 Apr;200:105281. (PMID: 35292289) |
فهرسة مساهمة: | Keywords: A(H1N1)pdm09; influenza viruses; monitoring; neuraminidase inhibitor; oseltamivir; permissive mutations; resistance; secondary mutations; surveillance |
المشرفين على المادة: | EC 3.2.1.18 (Neuraminidase) 0 (Antiviral Agents) 0 (Viral Proteins) 20O93L6F9H (Oseltamivir) EC 3.2.1.18 (NA protein, influenza A virus) |
تواريخ الأحداث: | Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729 |
رمز التحديث: | 20240729 |
مُعرف محوري في PubMed: | PMC11281601 |
DOI: | 10.3390/v16071109 |
PMID: | 39066271 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1999-4915 |
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DOI: | 10.3390/v16071109 |