دورية أكاديمية
أعرض في EDS

A Marek's Disease Virus Messenger RNA-Based Vaccine Modulates Local and Systemic Immune Responses in Chickens.

التفاصيل البيبلوغرافية
العنوان: A Marek's Disease Virus Messenger RNA-Based Vaccine Modulates Local and Systemic Immune Responses in Chickens.
المؤلفون: Fazel F; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Matsuyama-Kato A; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Alizadeh M; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Zheng J; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Fletcher C; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Gupta B; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., St-Denis M; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Boodhoo N; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Sharif S; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
المصدر: Viruses [Viruses] 2024 Jul 18; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Chickens*/immunology , Marek Disease*/prevention & control , Marek Disease*/immunology , Marek Disease*/virology , Marek Disease Vaccines*/immunology , Marek Disease Vaccines*/administration & dosage , Marek Disease Vaccines*/genetics , Cytokines*/metabolism , Cytokines*/immunology , Herpesvirus 2, Gallid*/immunology , Herpesvirus 2, Gallid*/genetics, Animals ; Lung/virology ; Lung/immunology ; Spleen/immunology ; Spleen/virology ; Poultry Diseases/prevention & control ; Poultry Diseases/immunology ; Poultry Diseases/virology ; mRNA Vaccines/immunology ; Vaccination ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics
مستخلص: Marek's disease (MD), caused by the Marek's disease virus, is a lymphoproliferative disease in chickens that can be controlled by vaccination. However, the current vaccines can limit tumor growth and death but not virus replication and transmission. The present study aimed to evaluate host responses following intramuscular injection of an mRNA vaccine encoding gB and pp38 proteins of the MDV within the first 36 h. The vaccine was injected in low and high doses using prime and prime-boost strategies. The expression of type I and II interferons (IFNs), a panel of interferon-stimulated genes, and two key antiviral cytokines, IL-1β and IL-2, were measured in spleen and lungs after vaccination. The transcriptional analysis of the above genes showed significant increases in the expression of MDA5, Myd88, IFN-α, IFN-β, IFN-γ, IRF7, OAS, Mx1, and IL-2 in both the spleen and lungs within the first 36 h of immunization. Secondary immunization increased expression of all the above genes in the lungs. In contrast, only IFN-γ, MDA5, MyD88, Mx1, and OAS showed significant upregulation in the spleen after the secondary immunization. This study shows that two doses of the MDV mRNA vaccine encoding gB and pp38 antigens activate innate and adaptive responses and induce an antiviral state in chickens.
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فهرسة مساهمة: Keywords: Marek’s disease virus; chicken; cytokines; immune response; mRNA vaccine
المشرفين على المادة: 0 (Marek Disease Vaccines)
0 (Cytokines)
0 (mRNA Vaccines)
0 (RNA, Messenger)
0 (Vaccines, Synthetic)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11281610
DOI: 10.3390/v16071156
PMID: 39066318
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v16071156