دورية أكاديمية
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Garcinol in gastrointestinal cancer prevention: recent advances and future prospects.

التفاصيل البيبلوغرافية
العنوان: Garcinol in gastrointestinal cancer prevention: recent advances and future prospects.
المؤلفون: Patwa N; Department of Chemistry, Indian Institute of Technology, Delhi, India., Chauhan R; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, 248002, India., Chauhan A; Amity Institute of Environmental Toxicology Safety and Management, Amity University, Noida, U.P, India., Kumar M; Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala, 134007, Haryana, India., Ramniwas S; University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, 140413, India., Mathkor DM; Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, 45142, Saudi Arabia., Saini AK; Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Ambala, India., Tuli HS; Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Ambala, India., Haque S; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, 11022801, Lebanon. shafiul.haque@hotmail.com., Slama P; Laboratory of Animal Immunology and Biotechnology, Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, 61300, Brno, Czech Republic. petr.slama@mendelu.cz.
المصدر: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2024 Jul 27; Vol. 150 (7), pp. 370. Date of Electronic Publication: 2024 Jul 27.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York : Springer-Verlag.
مواضيع طبية MeSH: Gastrointestinal Neoplasms*/prevention & control , Gastrointestinal Neoplasms*/drug therapy , Terpenes*/therapeutic use , Terpenes*/pharmacology, Humans ; Animals ; Antineoplastic Agents, Phytogenic/therapeutic use ; Antineoplastic Agents, Phytogenic/pharmacology
مستخلص: Gastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies. The objective is to review recent research on garcinol's anticancer properties, its mechanisms of action, and safety aspects. Garcinol exhibits anticancer effects in esophageal, gastric, colorectal, pancreatic, and liver cancers by inhibiting metastasis, inducing apoptosis, and targeting key molecular pathways in cancer progression. Nanotechnology is explored as a means to enhance garcinol delivery and efficacy. Safety assessments suggest a promising toxicity profile. Garcinol shows significant potential as a natural therapeutic agent for gastrointestinal cancers, and future research is needed on optimizing its delivery, exploring synergistic combinations, and conducting clinical trials to validate its efficacy and safety for clinical applications.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Apoptosis; Garcinol; Gastrointestinal cancers; Pharmacokinetics; Targeted therapy
المشرفين على المادة: TR1VR1V71B (garcinol)
0 (Terpenes)
0 (Antineoplastic Agents, Phytogenic)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240728
رمز التحديث: 20240729
DOI: 10.1007/s00432-024-05880-6
PMID: 39066940
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1335
DOI:10.1007/s00432-024-05880-6