دورية أكاديمية

Carbene-coated metal nanoparticles for in vivo applications.

التفاصيل البيبلوغرافية
العنوان: Carbene-coated metal nanoparticles for in vivo applications.
المؤلفون: Ivantcova PM; Sirius University of Science and Technology, Olimpiyskiy ave, b.1, Sirius, Krasnodar region 354340, Russian Federation. Electronic address: ivantsova.pm@talantiuspeh.ru., Kolychev EL; Moscow Center for Advanced Studies, Kulakova str. 20, Moscow 123592, Russian Federation. Electronic address: eugene.kolychev@gmail.com., Sizikov AA; Moscow Center for Advanced Studies, Kulakova str. 20, Moscow 123592, Russian Federation; Moscow Institute of Physics and Technology, Kerchenskaya str., 1А, Moscow 117303, Russian Federation., Mochalova EN; Sirius University of Science and Technology, Olimpiyskiy ave, b.1, Sirius, Krasnodar region 354340, Russian Federation; Moscow Center for Advanced Studies, Kulakova str. 20, Moscow 123592, Russian Federation; Moscow Institute of Physics and Technology, Kerchenskaya str., 1А, Moscow 117303, Russian Federation., Cherkasov VR; Moscow Center for Advanced Studies, Kulakova str. 20, Moscow 123592, Russian Federation; Moscow Institute of Physics and Technology, Kerchenskaya str., 1А, Moscow 117303, Russian Federation., Nikitin MP; Sirius University of Science and Technology, Olimpiyskiy ave, b.1, Sirius, Krasnodar region 354340, Russian Federation; Moscow Center for Advanced Studies, Kulakova str. 20, Moscow 123592, Russian Federation; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya str., 16/10, Moscow 117997, Russian Federation.
المصدر: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Jul 15; Vol. 242, pp. 114097. Date of Electronic Publication: 2024 Jul 15.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, c1993-
مستخلص: N-Heterocyclic carbenes (NHC) are well-recognized ligands of choice for preparing robust transition metal species. However, their use for fabrication of biomedically relevant nanoparticles has been limited to the synthesis of non-targeted particles showing increased tolerance to different aqueous coagulants. In this work, the first example of carbene-coated metal nanoparticles suitable for in vivo applications is presented. Directed design of a novel biscarbene NHC ligand allowed to prepare the first magnetite/gold (Fe 3 O 4 @AuNP@NHC) nanostructures and carbene gold (AuNP@NHC) nanoparticles with significant stability in aqueous solutions and enhanced ability to form bioconjugates. Furthermore, these nanoparticles exhibit an extraordinary property for inorganic nanoparticles: they can endure several additive-free air drying/redispersion cycles without deterioration of their colloidal behavior. Bioconjugated AuNP@NHC and multimodal Fe 3 O 4 @AuNP@NHC demonstrated a successful performance in three distinct applications: lateral flow tests, specific cancer cell targeting, and bioimaging. Thus, the results show the notable advantages of the N-heterocyclic carbene coating of inorganic nanoparticles and their utility for complex biomedical applications.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. The authors declare the following competing financial interest(s): P.M.I., E.L.K., E.N.M., M.P.N., A.A.S. are the authors of a related patent application filed by Sirius University of Science and Technology. M.P.N. and E.N.M. are stakeholders of Abisense LLC that manufactures the LumoTrace FLUO bioimaging system.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Gold nanoparticles; Magnetite-gold nanoparticles; N-heterocyclic carbenes; Nanobiomedicine; bioimaging; cell targeting; lateral flow assay
تواريخ الأحداث: Date Created: 20240727 Latest Revision: 20240727
رمز التحديث: 20240729
DOI: 10.1016/j.colsurfb.2024.114097
PMID: 39067190
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4367
DOI:10.1016/j.colsurfb.2024.114097