دورية أكاديمية
أعرض في EDS

Modulation of the intestinal mucosal and cell-mediated response against natural helminth infection in the African catfish Clarias gariepinus.

التفاصيل البيبلوغرافية
العنوان: Modulation of the intestinal mucosal and cell-mediated response against natural helminth infection in the African catfish Clarias gariepinus.
المؤلفون: Abdel-Hakeem SS; Parasitology Laboratory, Zoology and Entomology Department, Faculty of Science, Assiut University, Assiut, 71526, Egypt. sara_assiut86@aun.edu.eg., Fadladdin YAJ; Faculty of Sciences, Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Khormi MA; Department of Biology, College of Science, Jazan University, Saudi Arabia, P.O. Box. 114, Jazan, 45142, Kingdom of Saudi Arabia., Abd-El-Hafeez HH; Department of Cell and Tissues, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt. hhnnzz91@aun.edu.eg.
المصدر: BMC veterinary research [BMC Vet Res] 2024 Jul 27; Vol. 20 (1), pp. 335. Date of Electronic Publication: 2024 Jul 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2005-
مواضيع طبية MeSH: Catfishes*/parasitology , Fish Diseases*/parasitology , Fish Diseases*/immunology , Intestinal Mucosa*/parasitology , Intestinal Mucosa*/immunology , Helminthiasis, Animal*/parasitology, Animals ; Immunity, Cellular ; Vascular Endothelial Growth Factor A/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Intestinal Diseases, Parasitic/veterinary ; Intestinal Diseases, Parasitic/parasitology ; Intestinal Diseases, Parasitic/immunology ; Antigens, CD/metabolism
مستخلص: Fish gut is a versatile organ serving as the primary pathway for invasion by pathogens, particularly parasites, playing a crucial role in modulating the intestinal adaptive immune response. This study aimed to investigate the cellular-mediated reaction, mucosal acidity, and the expression of proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), and CD68 in the intestines of catfish, Clarias gariepinus, naturally infected with helminths. Forty catfish were collected from the Nile River and examined for intestinal parasites. The intestinal tissues of the control and infected fish were fixed for histochemical and immunohistochemical studies. Two groups of helminths were found: cestodes Tetracampos ciliotheca and Polyonchobothrium clarias, and nematodes Paracamallanus cyathopharynx, with a prevalence rate of 63.63%, 18.0%, and 18.0%, respectively. Our results showed that the infected fish had a statistically significant rise in the activity of immune cells, including mast cells, eosinophil granular cells, and dendritic cells. This correlated with upregulation in the expressions of PCNA, VEGF, and CD68. Histochemical analyses demonstrated a marked increase in acidic mucus production, Sudan black B, and bromophenol mercury blue. This study enriches our understanding of the evolution of vertebrate immunity in combating intestinal parasitic infections and the host's adaptive responses.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: CD68; Catfish; Histochemical; Intestinal immune cells; PCNA; VEGF
المشرفين على المادة: 0 (Vascular Endothelial Growth Factor A)
0 (Proliferating Cell Nuclear Antigen)
0 (Antigens, Differentiation, Myelomonocytic)
0 (Antigens, CD)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240730
رمز التحديث: 20240730
مُعرف محوري في PubMed: PMC11282724
DOI: 10.1186/s12917-024-04153-1
PMID: 39068442
قاعدة البيانات: MEDLINE
الوصف
تدمد:1746-6148
DOI:10.1186/s12917-024-04153-1