دورية أكاديمية
No evidence that post-training dopamine D2 receptor agonism affects fear generalization in male rats.
| العنوان: | No evidence that post-training dopamine D2 receptor agonism affects fear generalization in male rats. |
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| المؤلفون: | Schroyens N; Centre for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium., Vercammen L; Centre for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Laboratory of Biological Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium., Özcan B; Centre for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium., Ossorio Salazar VA; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Laboratory of Biological Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium., Zaman J; Health Psychology, KU Leuven, Leuven, Belgium., De Bundel D; Research Group Experimental Pharmacology, Department of Pharmaceutical Sciences, Center for Neurosciences, Vrije Universiteit Brussel, Brussel, Belgium., Beckers T; Centre for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium., Luyten L; Centre for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium. |
| المصدر: | Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2024 Jul; Vol. 38 (7), pp. 672-682. Date of Electronic Publication: 2024 Jul 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Thousand Oaks, CA : Sage Publications Original Publication: Oxford, UK : Oxford University Press, |
| مواضيع طبية MeSH: | Fear*/drug effects , Receptors, Dopamine D2*/agonists , Receptors, Dopamine D2*/metabolism , Quinpirole*/pharmacology , Dopamine Agonists*/pharmacology , Rats, Wistar* , Generalization, Psychological*/drug effects , Raclopride*/pharmacology , Conditioning, Classical*/drug effects, Animals ; Male ; Rats ; Dopamine D2 Receptor Antagonists/pharmacology |
| مستخلص: | Background: The neurotransmitter dopamine plays an important role in the processing of emotional memories, and prior research suggests that dopaminergic manipulations immediately after fear learning can affect the retention and generalization of acquired fear. Aims: The current study focuses specifically on the role of dopamine D2 receptors (D2Rs) regarding fear generalization in adult, male Wistar rats, and aims to replicate previous findings in mice. Methods: In a series of five experiments, D2R (ant)agonists were injected systemically, immediately after differential cued fear conditioning (CS+ followed by shock, CS- without shock). All five experiments involved the administration of the D2R agonist quinpirole at different doses versus saline ( n = 12, 16, or 44 rats/group). In addition, one of the studies administered the D2R antagonist raclopride ( n = 12). One day later, freezing during the CS+ and CS- was assessed. Results: We found no indications for an effect of quinpirole or raclopride on fear generalization during this drug-free test. Importantly, and contradicting earlier research in mice, the evidence for the absence of an effect of D2R agonist quinpirole (1 mg/kg) on fear generalization was substantial according to Bayesian analyses and was observed in a highly powered experiment ( N = 87). We did find acute behavioral effects in line with the literature, for both quinpirole and raclopride in a locomotor activity test. Conclusion: In contrast with prior studies in mice, we have obtained evidence against a preventative effect of post-training D2R agonist quinpirole administration on subsequent fear generalization in rats. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
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| فهرسة مساهمة: | Keywords: Differential cued fear conditioning; dopamine; generalization; quinpirole; raclopride; rats |
| المشرفين على المادة: | 0 (Receptors, Dopamine D2) 20OP60125T (Quinpirole) 0 (Dopamine Agonists) 430K3SOZ7G (Raclopride) 0 (Dopamine D2 Receptor Antagonists) |
| تواريخ الأحداث: | Date Created: 20240728 Date Completed: 20240730 Latest Revision: 20240811 |
| رمز التحديث: | 20240812 |
| مُعرف محوري في PubMed: | PMC7616352 |
| DOI: | 10.1177/02698811241261375 |
| PMID: | 39068641 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1461-7285 |
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| DOI: | 10.1177/02698811241261375 |