التفاصيل البيبلوغرافية
| العنوان: |
FGF Signaling Regulates Development of the Anterior Fontanelle. |
| المؤلفون: |
Bobzin L, Nickle A, Ko S, Ince M, Bhojwani A, Merrill AE |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 17. Date of Electronic Publication: 2024 Jul 17. |
| نوع المنشور: |
Journal Article; Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
The calvarial bones of the infant skull are connected by transient fibrous joints known as sutures and fontanelles, which are essential for reshaping during birth and postnatal growth. Genetic disorders such as Apert, Pfeiffer, Crouzon, and Bent bone dysplasia linked to FGFR2 variants often exhibit multi-suture craniosynostosis and a persistently open anterior fontanelle (AF). This study leverages mouse genetics and single-cell transcriptomics to determine how Fgfr2 regulates closure of the AF closure and its transformation into the frontal suture during postnatal development. We find that cells of the AF, marked by the tendon/ligament factor SCX, are spatially restricted to ecto- or endocranial domains and undergo regionally selective differentiation into ligament, bone, and cartilage. Differentiation of SCX+ AF cells is dependent on FGFR2 signaling in cells of the osteogenic fronts which, when fueled by FGF18 from the ectocranial mesenchyme, express the secreted WNT inhibitor WIF1 to regulate WNT signaling in neighboring AF cells. Upon loss of Fgfr2 , Wif1 expression is lost, and cells of the AF retain a connective tissue-like fate failing to form the posterior frontal suture. This study provides new insights into regional differences in suture development by identifying an FGF-WNT signaling circuit within the AF that links frontal bone advancement with suture joint formation. |
| تواريخ الأحداث: |
Date Created: 20240729 Latest Revision: 20240729 |
| رمز التحديث: |
20240729 |
| مُعرف محوري في PubMed: |
PMC11275813 |
| DOI: |
10.1101/2024.07.14.603452 |
| PMID: |
39071418 |
| قاعدة البيانات: |
MEDLINE |
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