دورية أكاديمية

Customized Vascular Repair Microenvironment: Poly(lactic acid)-Gelatin Nanofibrous Scaffold Decorated with bFGF and Ag@Fe 3 O 4 Core-Shell Nanowires.

التفاصيل البيبلوغرافية
العنوان: Customized Vascular Repair Microenvironment: Poly(lactic acid)-Gelatin Nanofibrous Scaffold Decorated with bFGF and Ag@Fe 3 O 4 Core-Shell Nanowires.
المؤلفون: Yang C; South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China., Yuan W; Guangdong Second Provincial General Hospital, Guangzhou 510317, China., Liao G; South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China., Tang Z; South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China., Zhu T; South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China., Jia Y; South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China., Yu Q; South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China., Wang L; South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China.; State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.
المصدر: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Aug 07; Vol. 16 (31), pp. 40787-40804. Date of Electronic Publication: 2024 Jul 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society
مواضيع طبية MeSH: Polyesters*/chemistry , Gelatin*/chemistry , Fibroblast Growth Factor 2*/chemistry , Fibroblast Growth Factor 2*/pharmacology , Silver*/chemistry , Nanofibers*/chemistry , Nanowires*/chemistry , Tissue Scaffolds*/chemistry, Animals ; Humans ; Blood Vessel Prosthesis ; Mice ; Human Umbilical Vein Endothelial Cells
مستخلص: Vascular defects caused by trauma or vascular diseases can significantly impact normal blood circulation, resulting in serious health complications. Vascular grafts have evolved as a popular approach for vascular reconstruction with promising outcomes. However, four of the greatest challenges for successful application of small-diameter vascular grafts are (1) postoperative anti-infection, (2) preventing thrombosis formation, (3) utilizing the inflammatory response to the graft to induce tissue regeneration and repair, and (4) noninvasive monitoring of the scaffold and integration. The present study demonstrated a basic fibroblast growth factor (bFGF) and oleic acid dispersed Ag@Fe 3 O 4 core-shell nanowires (OA-Ag@Fe 3 O 4 CSNWs) codecorated poly(lactic acid) (PLA)/gelatin (Gel) multifunctional electrospun vascular grafts (bAPG). The Ag@Fe 3 O 4 CSNWs have sustained Ag + release and exceptional photothermal capabilities to effectively suppress bacterial infections both in vitro and in vivo , noninvasive magnetic resonance imaging (MRI) modality to monitor the position of the graft, and antiplatelet adhesion properties to promise long-term patency. The gradually released bFGF from the bAPG scaffold promotes the M2 macrophage polarization and enhances the recruitment of macrophages, endothelial cells (ECs) and fibroblast cells. This significant regulation of diverse cell behavior has been proven to be beneficial to vascular repair and regeneration both in vitro and in vivo . Therefore, this study supplies a method to prepare multifunctional vascular-repair materials and is expected to represent a significant guidance and reference to the development of biomaterials for vascular tissue engineering.
فهرسة مساهمة: Keywords: antibacterial; electrospinning; macrophage; magnetic resonance imaging; tissue engineering scaffold; vascular grafts
المشرفين على المادة: 0 (Polyesters)
9000-70-8 (Gelatin)
459TN2L5F5 (poly(lactide))
103107-01-3 (Fibroblast Growth Factor 2)
3M4G523W1G (Silver)
تواريخ الأحداث: Date Created: 20240729 Date Completed: 20240808 Latest Revision: 20240808
رمز التحديث: 20240808
DOI: 10.1021/acsami.4c09269
PMID: 39072379
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-8252
DOI:10.1021/acsami.4c09269