دورية أكاديمية
Cell fate decision by a morphogen-transcription factor-chromatin modifier axis.
| العنوان: | Cell fate decision by a morphogen-transcription factor-chromatin modifier axis. |
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| المؤلفون: | Ming J; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Lin L; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Li J; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Wu L; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Fang S; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Huang T; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Fu Y; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Liu D; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Zhang W; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Li C; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Yang Y; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Huang Y; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Qin Y; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Kuang J; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, Zhejiang, China., Huang X; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China., Guo L; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Zhang X; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Liu J; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Chen J; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Zhao C; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China. zhaochengchen@westlake.edu.cn., Wang B; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China. wangbo@westlake.edu.cn.; Zhejiang University of Science and Technology, School of Information and Electronic Engineering, Hangzhou, Zhejiang, China. wangbo@westlake.edu.cn.; Key Laboratory of Biomedical Intelligent Computing Technology of Zhejiang Province, Hangzhou, Zhejiang, China. wangbo@westlake.edu.cn., Pei D; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China. peiduanqing@westlake.edu.cn.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, Zhejiang, China. peiduanqing@westlake.edu.cn. |
| المصدر: | Nature communications [Nat Commun] 2024 Jul 29; Vol. 15 (1), pp. 6365. Date of Electronic Publication: 2024 Jul 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Transcription Factors*/metabolism , Transcription Factors*/genetics , Bone Morphogenetic Protein 4*/metabolism , Mi-2 Nucleosome Remodeling and Deacetylase Complex*/metabolism , Mi-2 Nucleosome Remodeling and Deacetylase Complex*/genetics , Cell Differentiation*, Animals ; Mice ; Chromatin/metabolism ; Gene Regulatory Networks ; Fibroblasts/metabolism ; Gene Expression Regulation, Developmental ; Endoderm/metabolism ; Endoderm/cytology ; Signal Transduction ; Cell Lineage ; DNA-Binding Proteins |
| مستخلص: | Cell fate decisions remain poorly understood at the molecular level. Embryogenesis provides a unique opportunity to analyze molecular details associated with cell fate decisions. Works based on model organisms have provided a conceptual framework of genes that specify cell fate control, for example, transcription factors (TFs) controlling processes from pluripotency to immunity 1 . How TFs specify cell fate remains poorly understood. Here we report that SALL4 relies on NuRD (nucleosome-remodeling and deacetylase complex) to interpret BMP4 signal and decide cell fate in a well-controlled in vitro system. While NuRD complex cooperates with SALL4 to convert mouse embryonic fibroblasts or MEFs to pluripotency, BMP4 diverts the same process to an alternative fate, PrE (primitive endoderm). Mechanistically, BMP4 signals the dissociation of SALL4 from NuRD physically to establish a gene regulatory network for PrE. Our results provide a conceptual framework to explore the rich landscapes of cell fate choices intrinsic to development in higher organisms involving morphogen-TF-chromatin modifier pathways. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 92068201 National Natural Science Foundation of China (National Science Foundation of China); 32200662 National Natural Science Foundation of China (National Science Foundation of China) |
| المشرفين على المادة: | 0 (Transcription Factors) 0 (Bone Morphogenetic Protein 4) EC 3.5.1.98 (Mi-2 Nucleosome Remodeling and Deacetylase Complex) 0 (Sall4 protein, mouse) 0 (Chromatin) 0 (Bmp4 protein, mouse) 0 (DNA-Binding Proteins) |
| تواريخ الأحداث: | Date Created: 20240729 Date Completed: 20240729 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| مُعرف محوري في PubMed: | PMC11286941 |
| DOI: | 10.1038/s41467-024-50144-z |
| PMID: | 39075094 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-50144-z |