دورية أكاديمية
أعرض في EDS

[Interim efficacy of a multicenter cohort study for China Net Childhood Lymphoma mature B-cell lymphoma 2017 regimen in the treatment of pediatric High-grade-B cell lymphoma].

التفاصيل البيبلوغرافية
العنوان: [Interim efficacy of a multicenter cohort study for China Net Childhood Lymphoma mature B-cell lymphoma 2017 regimen in the treatment of pediatric High-grade-B cell lymphoma].
المؤلفون: Zhao Y; Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China., Huang S; Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing 100045, China., Jia YP; Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China., Zhang LP; Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China., Duan YL; Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing 100045, China., Jin L; Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing 100045, China., Zhai XW; Department of Hematology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China., Wang HS; Department of Hematology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China., Hu B; Department of Pediatric Lymphoma, Beijing GoBroad Boren Hospital, Beijing 100070, China., Liu Y; Department of Pediatric Lymphoma, Beijing GoBroad Boren Hospital, Beijing 100070, China., Liu AS; Department of Hematology & Oncology, Xi'an Children's Hospital, Xi'an 710002, China., Liu W; Department of Hematology & Oncology, Zhengzhou Children's Hospital, Zhengzhou 450018, China., Zheng MC; Department of Hematology, Hunan Children's Hospital, Changsha 410007, China., Li F; Hematology & Oncology Department, Children's Hospital Affiliated to Shandong University, Jinan 250022, China., Sun LR; Department of Pediatric Hematology & Oncology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China., Yuan XJ; Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China., Dai YP; Department of Pediatric Hematology & Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China., Zhang BX; Department of Pediatrics, Second Hospital of Hebei Medical University, Shijiazhuang 050004, China., Jiang L; Department of Pediatrics, Forth Hospital of Hebei Medical University, Shijiazhuang 050004, China., Wang XG; Department of Hematology and Oncology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Wang HM; Department of Pediatric Hematology & Endocrinology, First Hospital of Shandong First Medical University, Jinan 250021, China., Zhou CJ; Pathology Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China., Gao ZF; Department of Pathology, Peking University Third Hospital, Beijing 100191, China;Zhao Yang and Huang Shuang contributed equally to the artical., Zhang YH; Department of Pediatric Lymphoma, Beijing GoBroad Boren Hospital, Beijing 100070, China.
المصدر: Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2024 Jul 30; Vol. 104 (29), pp. 2751-2758.
نوع المنشور: Journal Article; Multicenter Study; English Abstract
اللغة: Chinese
بيانات الدورية: Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7511141 Publication Model: Print Cited Medium: Print ISSN: 0376-2491 (Print) Linking ISSN: 03762491 NLM ISO Abbreviation: Zhonghua Yi Xue Za Zhi Subsets: MEDLINE
أسماء مطبوعة: Publication: Beijing : Zhonghua yi xue hui
Original Publication: Beijing : Zhonghua yi xue hui.
مواضيع طبية MeSH: Lymphoma, B-Cell*/drug therapy , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Retrospective Studies ; Child ; China ; Adolescent ; Female ; Male ; Proto-Oncogene Proteins c-bcl-6/genetics ; Cohort Studies ; Proto-Oncogene Proteins c-bcl-2/genetics ; Child, Preschool ; In Situ Hybridization, Fluorescence ; Treatment Outcome ; Proto-Oncogene Proteins c-myc/genetics
مستخلص: Objective: To analyze the mid-term efficacy of the China Net Childhood Lymphoma mature B-cell lymphoma 2017 (CNCL-B-NHL-2017) regimen in treating children with high-grade B-cell lymphoma (HGBL). Methods: Clinical and pathological data of HGBL children aged≤18 years admitted to 16 hospitals of the Chinese Children's Lymphoma Collaborative Group (CNCL) from May 2017 to April 2021 were collected retrospectively. They were divided in to high-grade B-cell lymphoma with double hit/triple hit (HGBL-DH/TH) group and high-grade B-cell lymphoma non-specified (HGBL-NOS) group, according to the 2016 version of the World Health Organization (WHO) Hematopoietic and Lymphoid Tissues Cancer Classification. Both groups of patients were treated with stratified chemotherapy by risk according to the CNCL-B-NHL-2017 scheme. The deadline for follow-up was December 31, 2023. All the patients were examined by chromosome fluorescence in situ hybridization (FISH), and the rearrangement of genes MYC, BCL-2 and BCL-6 was confirmed. The clinical and pathological characteristics of patients at disease onset were analyzed, and the therapeutic effects of patients in different clinical stages and risk groups were compared. Survival analysis was drawn by Kaplan Meier method, the log-rank test was used to compare the differences in the cumulative survival rate between different groups, and multivariate Cox regression model was used to identify the prognostic factors. Results: A total of 62 patients were included, with an onset age [ M ( Q 1 , Q 3 )] of 7 (4, 11) years, including 48 males and 14 females. There were 11 (17.7%) patients in stageⅡ, 33(53.2%)patients in stage Ⅲ and 18(29.1%)patients in stage Ⅳ. FISH testing showed that 4 cases (6.5%) were HGBL-DH and 3 (4.8%) were HGBL-TH. The remaining 55 cases (88.7%) were HGBL-NOS, with 18 cases accompanied by MYC rearrangement. There were 7 cases in the HGBL-DH/TH group and 55 cases in the HGBL-NOS group. Thirteen cases (20.9%) were treated with the B1 regimen, 3 cases (4.8%) with B2 regimen, 37 cases (59.6%) with C1 regimen, and 9 cases (14.7%) with the C2 regimen. Forty-eight cases (77.4%) received rituximab therapy at the same time. Five cases (8.0%) progressed during treatment. The follow-up time [ M ( Q 1 , Q 3 )] was 43.5 (36.1, 53.7) months. The complete remission rate was 91.9% (57/62). The 3 year overall survival rate was 93.5% and event-free survival (EFS) rate was 91.9%. The 3-year overall survival rate in the HGBL-NOS group was higher than that in the HGBL-DH/TH group (96.3% vs 71.4%, P =0.011). The 3-year EFS rate of the HGBL-NOS group was higher than that of the HGBL-DH/TH group (94.5% vs 71.4%, P =0.037). In the HGBL-NOS subgroup, the overall survival rate of children with MYC rearrangement was lower (100% vs 88.9%, P =0.039). Multivariate Cox regression analysis showed that central invasion ( HR =6.05, 95% CI : 1.96-38.13, P =0.046) was a risk factor for overall survival. Conclusion: CNCL-B-NHL-2017 regimen shows significant effects in the treatment of pediatric HGBL, with a good prognosis.
معلومات مُعتمدة: 2199000726 The Foundation of 2018 Beijing Key Clinical Specialty Construction Project Pediatrics
فهرسة مساهمة: Local Abstract: [Publisher, Chinese] 目的： 分析中国儿童淋巴瘤协作组成熟B细胞淋巴瘤2017（CNCL-B-NHL-2017）方案治疗儿童高级别B细胞淋巴瘤（HGBL）的中期疗效。 方法： 回顾性收集中国儿童淋巴瘤协作组（CNCL）16家医院2017年5月至2021年4月收治的年龄≤18岁的HGBL患儿的临床及病理资料，根据2016版世界卫生组织（WHO）造血和淋巴组织肿瘤分类，分为高级别B细胞淋巴瘤伴双打击/三打击（HGBL-DH/TH）组及高级别B细胞淋巴瘤-非特指型（HGBL-NOS）组。2组患儿均根据CNCL-B-NHL-2017方案，并按照危险度分层化疗，随访截止日期为2023年12月31日。所有患儿均行染色体荧光原位杂交（FISH）检查，以明确基因MYC、BCL-2及BCL-6重排情况。分析患儿发病时临床、病理特点，比较不同临床分期、危险度分组患儿的治疗效果，采用Kaplan-Meier法绘制生存曲线，log-rank检验比较组间累积生存率的差异，多因素Cox回归模型分析预后的影响因素。 结果： 共纳入62例患儿，发病年龄［ M （ Q 1 ， Q 3 ）］为7（4，11）岁，男48例、女14例。临床分期Ⅱ、Ⅲ、Ⅳ期分别有11例（17.7%）、33例（53.2%）、18例（29.1%）。FISH检测结果显示4例（6.5%）为HGBL-DH；3例（4.8%）为HGBL-TH；余55例（88.7%）均为HGBL-NOS，其中18例伴MYC基因重排。HGBL-DH/TH组有7例，HGBL-NOS组有55例。B1方案13例（20.9%），B2方案3例（4.8%），C1方案37例（59.6%）和C2方案9例（14.7%）。48例（77.4%）同时联合利妥昔单抗靶向治疗。5例（8.0%）治疗中进展。随访时间［ M （ Q 1 ， Q 3 ）］为43.5（36.1，53.7）个月，所有患儿的完全缓解率为91.9%（57/62）。3年总生存率和无事件生存率分别为93.5%和91.9%。HGBL-NOS组患儿的3年总生存率高于HGBL-DH/TH组（96.3%比71.4%， P =0.011）。HGBL-NOS组3年无事件生存率高于HGBL-DH/TH组（94.5%比71.4%， P =0.037）。在HGBL-NOS亚组中，伴有MYC基因重排的患儿总生存率较低（100%比88.9%， P =0.039）。多因素Cox回归分析显示，中枢神经系统侵犯（ HR =6.05，95% CI ：1.96~38.13， P =0.046）是总生存率的危险因素。 结论： 应用CNCL-B-NHL-2017方案治疗儿童HGBL疗效显著，预后良好。.
المشرفين على المادة: 0 (Proto-Oncogene Proteins c-bcl-6)
0 (BCL6 protein, human)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (Proto-Oncogene Proteins c-myc)
تواريخ الأحداث: Date Created: 20240730 Date Completed: 20240730 Latest Revision: 20240730
رمز التحديث: 20240730
DOI: 10.3760/cma.j.cn112137-20240305-00490
PMID: 39075995
قاعدة البيانات: MEDLINE
الوصف
تدمد:0376-2491
DOI:10.3760/cma.j.cn112137-20240305-00490