دورية أكاديمية
Illicit Fentanyl Use and Hepatitis C Virus Seroconversion Among People Who Inject Drugs in Tijuana and San Diego: Results From a Binational Cohort Study.
| العنوان: | Illicit Fentanyl Use and Hepatitis C Virus Seroconversion Among People Who Inject Drugs in Tijuana and San Diego: Results From a Binational Cohort Study. |
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| المؤلفون: | Friedman JR; Department of Psychiatry, San Diego., Abramovitz D; Department of Medicine, University of California, San Diego., Skaathun B; Department of Medicine, University of California, San Diego., Rangel G; Department of Population Studies, Colegio de la Frontera Norte.; Sección mexicana, Comisión de Salud Fronteriza México-Estados Unidos., Harvey-Vera A; Department of Medicine, University of California, San Diego., Vera CF; Department of Medicine, University of California, San Diego.; Sección mexicana, Comisión de Salud Fronteriza México-Estados Unidos., Artamonova I; Department of Medicine, University of California, San Diego., Muñoz S; Sección mexicana, Comisión de Salud Fronteriza México-Estados Unidos.; Escuela de Medicina, Universidad Xochicalco, Campus Tijuana, Mexico., Martin NK; Department of Medicine, University of California, San Diego., Eger WH; Department of Medicine, University of California, San Diego.; School of Social Work, San Diego State University, California., Bailey K; Department of Medicine, University of California, San Diego., Go BS; School of Medicine, University of Amsterdam, The Netherlands., Bourgois P; Department of Psychiatry, San Diego., Strathdee SA; Department of Medicine, University of California, San Diego. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مستخلص: | Background: Illicitly manufactured fentanyl (IMF) increases overdose mortality, but its role in infectious disease transmission is unknown. We examined whether IMF use predicts hepatitis C virus (HCV) and human immunodeficiency virus (HIV) incidence among a cohort of people who inject drugs (PWID) in San Diego, California and Tijuana, Mexico. Methods: PWID were recruited during 2020-2022, undergoing semi-annual interviewer-administered surveys and HIV and HCV serological rapid tests through 2024. Cox regression was conducted to examine predictors of seroconversion considering self-reported IMF use as a 6-month lagged, time-dependent covariate. Results: Of 398 PWID at baseline, 67% resided in San Diego, 70% were male, median age was 43 years, 42% reported receptive needle sharing, and 25% reported using IMF. HCV incidence was 14.26 per 100 person-years (95% confidence interval [CI]: 11.49-17.02), and HIV incidence was 1.29 (95% CI: .49-2.10). IMF was associated with HCV seroconversion, with a univariable hazard ratio (HR) of 1.64 (95% CI: 1.09-2.40), and multivariable HR of 1.57 (95% CI: 1.03-2.40). The direction of the relationship with HIV was similar, albeit not significant (HR 2.39; 95% CI: .66-8.64). Conclusions: We document a novel association between IMF and HCV seroconversion among PWID in Tijuana-San Diego. Few HIV seroconversions (n = 10) precluded our ability to assess if a similar relationship held for HIV. IMF's short half-life may destabilize PWID-increasing the need for repeat dosing and sharing smoking materials and syringes. New preventive care approaches may reduce HCV transmission in the fentanyl era. Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| معلومات مُعتمدة: | San Diego Center for AIDS Research; P30AI036214 National Institute of Allergy and Infectious Diseases; R01DA049644-S1 United States DA NIDA NIH HHS |
| فهرسة مساهمة: | Keywords: fentanyl use; hepatitis C virus; human immunodeficiency virus; infectious disease transmission; substance use disorders |
| تواريخ الأحداث: | Date Created: 20240730 Latest Revision: 20240730 |
| رمز التحديث: | 20240730 |
| DOI: | 10.1093/cid/ciae372 |
| PMID: | 39078273 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciae372 |