دورية أكاديمية
DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults.
| العنوان: | DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults. |
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| المؤلفون: | Glover L; Department of Population Health Sciences, 215 Morris Street, Duke University School of Medicine, Durham, NC 27701, United States., Lilly AG; Department of Sociology, 102 Emerson Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.; Carolina Population Center, 123 West Franklin Street, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, United States., Justice AE; Department of Population Health Sciences, 100 Academy Avenue, Geisinger Health, Danville, PA, United States., Howard AG; Carolina Population Center, 123 West Franklin Street, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, United States.; Department of Biostatistics, 135 Dauer Drive, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States., Staley BS; Carolina Population Center, 123 West Franklin Street, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, United States.; Department of Epidemiology, 135 Dauer Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States., Wang Y; Department of Epidemiology, 135 Dauer Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States., Kamens HM; Department of Biobehavioral Health, 219 Biobehavioral Health Building, 296 Henderson Drive, College of Health and Human Development, Pennsylvania State University, University Park, PA 16802, United States., Ferrier K; Department of Biomedical Informatics, 1890 North Revere Court, University of Colorado Anshutz Medical Campus, Aurora, CO, 80045, United States., Bressler J; Department of Epidemiology, Human Genetics & Environmental Sciences, 1200 Pressler Street, UTHealth Houston School of Public Health, Houston, TX 77030, United States., Loehr L; Department of Epidemiology, 135 Dauer Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States., Raffield LM; Department of Genetics, 120 Mason Farm Road, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States., Sims M; Department of Social Medicine, Population, and Public Health, 900 University Avenue, University of California Riverside, Riverside, CA 92521, United States., North KE; Department of Epidemiology, 135 Dauer Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States., Fernández-Rhodes L; Department of Epidemiology, 135 Dauer Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.; Department of Biobehavioral Health, 219 Biobehavioral Health Building, 296 Henderson Drive, College of Health and Human Development, Pennsylvania State University, University Park, PA 16802, United States. |
| المصدر: | Human molecular genetics [Hum Mol Genet] 2024 Jul 31. Date of Electronic Publication: 2024 Jul 31. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, England ; New York : IRL Press at Oxford University Press, c1992- |
| مستخلص: | Obesity and poverty disproportionally affect African American persons. Epigenetic mechanisms could partially explain the association between socioeconomic disadvantage and body mass index (BMI). We examined the extent to which epigenetic mechanisms mediate the effect of socioeconomic status (SES) on BMI. Using data from African American adults from the Atherosclerosis Risk in Communities (ARIC) Study (n = 2664, mean age = 57 years), education, income, and occupation were used to create a composite SES score at visit 1 (1987-1989). We conducted two methylation-wide association analyses to identify associations between SES (visit 1), BMI and cytosine-phosphate-guanine (CpG) sites measured at a subsequent visit (1990-1995). We then utilized structural equation modeling (SEM) to test whether identified sites mediated the association between earlier SES and BMI in sex-stratified models adjusted for demographic and risk factor covariates. Independent replication and meta-analyses were conducted using the Jackson Heart Study (JHS, n = 874, mean age 51 years, 2000-2004). Three CpG sites near MAD1L1, KDM2B, and SOCS3 (cg05095590, cg1370865, and cg18181703) were suggestively associated (P-value < 1.3×10-5) in ARIC and at array-wide significance (P-value < 1.3×10-7) in a combined meta-analysis of ARIC with JHS. SEM of these three sites revealed significant indirect effects in females (P-value < 5.8×10-3), each mediating 7%-20% of the total effect of SES on BMI. Nominally significant indirect effects were observed for two sites near MAD1L1 and KDM2B in males (P-value < 3.4×10-2), mediating -17 and -22% of the SES-BMI effect. These results provide further evidence that epigenetic modifications may be a potential pathway through which SES may "get under the skin" and contribute to downstream health disparities. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | Atherosclerosis Risk in Communities; United States HL NHLBI NIH HHS; United States NH NIH HHS; 75N92022D00001 United States HH HHS; HHSN268201800013I United States MD NIMHD NIH HHS; HHSN268201800014I United States HB NHLBI NIH HHS; HHSN268201800015I United States HB NHLBI NIH HHS; HHSN268201800010I United States HB NHLBI NIH HHS; National Institute for Minority Health and Health Disparities |
| فهرسة مساهمة: | Keywords: epigenetics; health disparities; methylation; obesity; socioeconomic status |
| تواريخ الأحداث: | Date Created: 20240730 Latest Revision: 20240730 |
| رمز التحديث: | 20240731 |
| DOI: | 10.1093/hmg/ddae112 |
| PMID: | 39079086 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1460-2083 |
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| DOI: | 10.1093/hmg/ddae112 |