دورية أكاديمية
Advancements and Challenges in Antiamyloid Therapy for Alzheimer's Disease: A Comprehensive Review.
العنوان: | Advancements and Challenges in Antiamyloid Therapy for Alzheimer's Disease: A Comprehensive Review. |
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المؤلفون: | Beshir SA; Department of Pharmacy Practice Dubai Pharmacy College for Girls, Dubai, UAE., Hussain N; Department of Pharmaceutical Sciences College of Pharmacy Al Ain University, Al Ain, UAE.; AAU Health and Biomedical Research Centre Al Ain University, Abu Dhabi, UAE., Menon VB; Department of Pharmacy Practice College of Pharmacy Gulf Medical University, Ajman, UAE., Al Haddad AHI; Chief Operations Office Sheikh Shakhbout Medical City (SSMC) PureHealth, Abu Dhabi, UAE., Al Zeer RAK; Dubai Pharmacy College for Girls, Dubai, UAE., Elnour AA; AAU Health and Biomedical Research Centre Al Ain University, Abu Dhabi, UAE.; College of Pharmacy Al Ain University Abu Dhabi Campus, Abu Dhabi, UAE. |
المصدر: | International journal of Alzheimer's disease [Int J Alzheimers Dis] 2024 Jul 23; Vol. 2024, pp. 2052142. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Country of Publication: United States NLM ID: 101525141 Publication Model: eCollection Cited Medium: Print ISSN: 2090-8024 (Print) NLM ISO Abbreviation: Int J Alzheimers Dis Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2011- : New York : Hindawi Original Publication: London, England ; New York, NY : SAGE-Hindawi Access to Research, |
مستخلص: | Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused by the accumulation of amyloid-beta (A β ) proteins and neurofibrillary tangles in the brain. There have been recent advancements in antiamyloid therapy for AD. This narrative review explores the recent advancements and challenges in antiamyloid therapy. In addition, a summary of evidence from antiamyloid therapy trials is presented with a focus on lecanemab. Lecanemab is the most recently approved monoclonal antibody that targets A β protofibrils for the treatment of patients with early AD and mild cognitive impairment (MCI). Lecanemab was the first drug shown to slow cognitive decline in patients with MCI or early onset AD dementia when administered as an infusion once every two weeks. In the Clarity AD trial, lecanemab was associated with infusion-site reactions (26.4%) and amyloid-related imaging abnormalities (12.6%). The clinical relevance and long-term side effects of lecanemab require further longitudinal observation. However, several challenges must be addressed before the drug can be routinely used in clinical practice. The drug's route of administration, need for imaging and genetic testing, affordability, accessibility, infrastructure, and potential for serious side effects are some of these challenges. Lecanemab's approval has fueled interest in the potential of other antiamyloid therapies, such as donanemab. Future research must focus on developing strategies to prevent AD; identify easy-to-use validated plasma-based assays; and discover newer user-friendly, and cost-effective drugs that target multiple pathways in AD pathology. Competing Interests: The authors do not have any conflicts of interest to disclose. (Copyright © 2024 Semira Abdi Beshir et al.) |
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تواريخ الأحداث: | Date Created: 20240731 Latest Revision: 20240801 |
رمز التحديث: | 20240801 |
مُعرف محوري في PubMed: | PMC11288696 |
DOI: | 10.1155/2024/2052142 |
PMID: | 39081336 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2090-8024 |
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DOI: | 10.1155/2024/2052142 |