Factors associated with non-prescription of oseltamivir for infant influenza over nine seasons.

التفاصيل البيبلوغرافية
العنوان:	Factors associated with non-prescription of oseltamivir for infant influenza over nine seasons.
المؤلفون:	Zaheer HA; Department of Ophthalmology, UPMC Eye Institute, Pittsburgh, PA, USA.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Moehling Geffel K; Department of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Chamseddine S; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Liu H; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Williams JV; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Martin JM; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rick AM; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
المصدر:	Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2024 Jul 31. Date of Electronic Publication: 2024 Jul 31.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Oxford University Press Country of Publication: England NLM ID: 101586049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2048-7207 (Electronic) Linking ISSN: 20487193 NLM ISO Abbreviation: J Pediatric Infect Dis Soc Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford : Oxford University Press
مستخلص:	Background/objective: The Centers for Disease Control and Prevention (CDC) recommends oseltamivir phosphate for children <2 years old with confirmed or suspected influenza as they are at high risk for complications. We analyzed infant characteristics associated with non-prescription of oseltamivir over nine years. Methods: We conducted a retrospective electronic health record (EHR) review of infants <12 months old born between January 1, 2012 and December 31, 2019 within the UPMC health system in Southwestern Pennsylvania who had >2 well-child visits during their first year. Infants with a confirmed positive test for influenza were included in the analysis. Factors associated with infant oseltamivir non-prescription were assessed using multivariable logistic regression. Results: Of 457 infants with confirmed influenza, 86% were prescribed oseltamivir. The proportion of infants prescribed oseltamivir increased from an average of 64.6% during 2012-2016 influenza seasons to 90.4% during 2016-2020 influenza seasons. Infants were more likely to not be prescribed oseltamivir if they experienced >2 days of influenza symptoms (OR: 9.4, 95% CI: 4.8, 18.7, P< 0.001), were diagnosed during the 2012-2016 influenza seasons (OR: 4.2, 95% CI: 1.8, 9.5, P<0.001), tested positive for influenza via a multiplex/RT-PCR test (OR: 6.7, 95% CI: 2.7, 16.3, P<0.001; OR: 2.7, 95% CI: 1.1, 7.1; P=0.04), or did not have a fever at point-of-care (OR: 2.3, 95% CI: 1.2, 4.6, P=0.01). Conclusion: Adherence to CDC influenza antiviral treatment guidelines for infants is high and improved over time. However, provision of targeted education to providers may further improve oseltamivir prescribing practices for high-risk children <12 months of age. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
تواريخ الأحداث:	Date Created: 20240731 Latest Revision: 20240731
رمز التحديث:	20240731
DOI:	10.1093/jpids/piae075
PMID:	39082694
قاعدة البيانات:	MEDLINE

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تدمد:	2048-7207
DOI:	10.1093/jpids/piae075