دورية أكاديمية
Sodium arsenite induces aggresome formation by promoting PICK1 BAR domain homodimer formation.
| العنوان: | Sodium arsenite induces aggresome formation by promoting PICK1 BAR domain homodimer formation. |
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| المؤلفون: | Lai JHC; Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom., Tsogka M; Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Xia J; Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; The Brain and Intelligence Research Institute, and Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Nansha, Guangzhou, China. |
| المصدر: | Molecular biology of the cell [Mol Biol Cell] 2024 Oct 01; Vol. 35 (10), pp. ar128. Date of Electronic Publication: 2024 Jul 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Cell Biology Country of Publication: United States NLM ID: 9201390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-4586 (Electronic) Linking ISSN: 10591524 NLM ISO Abbreviation: Mol Biol Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Society for Cell Biology, c1992- |
| مواضيع طبية MeSH: | Arsenites*/pharmacology , Arsenites*/toxicity , Sodium Compounds*/pharmacology , Nuclear Proteins*/metabolism , Carrier Proteins*/metabolism, Humans ; HEK293 Cells ; Protein Domains ; Protein Aggregates/drug effects ; Protein Multimerization/drug effects ; Ubiquitin/metabolism |
| مستخلص: | The aggresome is a perinuclear structure that sequesters misfolded proteins. It is implicated in various neurodegenerative diseases. The perinuclear structure enriched with protein interacting with C kinase 1 (PICK1) was found to be inducible by cellular stressors, colocalizing with microtubule-organizing center markers and ubiquitin, hence classifying it as an aggresome. Sodium arsenite but not arsenate was found to potently induce aggresome formation through an integrated stress response-independent pathway. In HEK293T cells, under arsenite stress, PICK1 localization to the aggresome was prioritized, and formation of PICK1 homodimers was favored. Additionally, PICK1 could enhance protein entry into aggresomes. This study shows that arsenite can induce the formation of both RNA stress granules and aggresomes at the same time, and that PICK1 shows conditional localization to aggresomes, suggesting a possible involvement of PICK1 in neurodegenerative diseases. Competing Interests: Conflicts of interest: The authors declare that no conflict of interest exists. |
| المشرفين على المادة: | 0 (Arsenites) 0 (Sodium Compounds) 48OVY2OC72 (sodium arsenite) 0 (Nuclear Proteins) 0 (Carrier Proteins) 0 (PICk1 protein, human) 0 (Protein Aggregates) 0 (Ubiquitin) |
| تواريخ الأحداث: | Date Created: 20240731 Date Completed: 20240920 Latest Revision: 20240920 |
| رمز التحديث: | 20240921 |
| DOI: | 10.1091/mbc.E24-05-0201 |
| PMID: | 39083353 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1939-4586 |
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| DOI: | 10.1091/mbc.E24-05-0201 |