Editorial & Opinion
Letter to editor: Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia.
| العنوان: | Letter to editor: Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia. |
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| المؤلفون: | Rizvi SVZ; Jinnah Sindh Medical University, Karachi, Pakistan., Zaidi SMF; Dow University of Health Sciences, Karachi, Pakistan. mahrukhfatima2010@live.com. |
| المصدر: | Neurosurgical review [Neurosurg Rev] 2024 Aug 01; Vol. 47 (1), pp. 383. Date of Electronic Publication: 2024 Aug 01. |
| نوع المنشور: | Letter |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Berlin Heidelberg Country of Publication: Germany NLM ID: 7908181 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-2320 (Electronic) Linking ISSN: 03445607 NLM ISO Abbreviation: Neurosurg Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Berlin Heidelberg Original Publication: Berlin : Walter De Gruyter |
| مواضيع طبية MeSH: | Subarachnoid Hemorrhage*/complications , Subarachnoid Hemorrhage*/drug therapy , Vasospasm, Intracranial*/drug therapy , Vasospasm, Intracranial*/prevention & control , Vasospasm, Intracranial*/etiology , Nimodipine*/therapeutic use , Neuroprotective Agents*/therapeutic use , Brain Ischemia*/drug therapy , Brain Ischemia*/prevention & control, Humans ; Neuroprotection/drug effects ; Cilostazol/therapeutic use |
| مستخلص: | This critique discusses neuroprotective strategies for aneurysmal subarachnoid hemorrhage (SAH), excluding Nimodipine, emphasizing alternatives like verapamil, albumin, and cilostazol. While these options show potential, their efficacy lacks robust confirmation from randomized controlled trials (RCTs), relying mainly on observational studies and small trials. The letter underscores the need for comprehensive safety assessments and long-term outcome studies to enhance practical application. Highlighting ongoing trials and emerging therapies like clazosentan and TAK-044, it advocates for future research directions focused on large-scale RCTs and combination therapies, such as cilostazol and Nimodipine, which have demonstrated synergistic benefits in reducing delayed cerebral ischemia (DCI) and improving patient outcomes. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| References: | Luzzi S, Bektaşoğlu PK, Doğruel Y, Güngor A (2024) Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia. Neurosurg Rev 47(1):305. https://doi.org/10.1007/s10143-024-02543-5 . PMID: 38967704; PMCID: PMC11226492. (PMID: 10.1007/s10143-024-02543-53896770411226492) Carlson AP, Hänggi D, Macdonald RL, Shuttleworth CW (2020) Nimodipine reappraised: An Old Drug with a future. Curr Neuropharmacol 18(1):65–82. https://doi.org/10.2174/1570159X17666190927113021 . PMID: 31560289; PMCID: PMC7327937. (PMID: 10.2174/1570159X17666190927113021315602897327937) Smetana KS, Buschur PL, Owusu-Guha J, May CC (2020) Apr/Jun;43(2):138–156 Pharmacologic Management of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage. Crit Care Nurs Q. https://doi.org/10.1097/CNQ.0000000000000299 . PMID: 32084059. Dawley T, Claus CF, Tong D, Rajamand S, Sigler D, Bahoura M, Garmo L, Soo TM, Kelkar P, Richards B (2020) Efficacy and safety of cilostazol-nimodipine combined therapy on delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage: a prospective, randomised, double-blinded, placebo-controlled trial protocol. BMJ Open 10(10):e036217. https://doi.org/10.1136/bmjopen-2019-036217 . PMID: 33020083; PMCID: PMC7537439. (PMID: 10.1136/bmjopen-2019-036217330200837537439) |
| فهرسة مساهمة: | Keywords: Calcium channel blockers; Cerebral vasospasm; Delayed cerebral ischemia; Nimodipine; Rho-kinase inhibitors; Subarachnoid hemorrhage |
| المشرفين على المادة: | 57WA9QZ5WH (Nimodipine) 0 (Neuroprotective Agents) N7Z035406B (Cilostazol) |
| تواريخ الأحداث: | Date Created: 20240731 Date Completed: 20240801 Latest Revision: 20240731 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1007/s10143-024-02617-4 |
| PMID: | 39085665 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1437-2320 |
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| DOI: | 10.1007/s10143-024-02617-4 |