دورية أكاديمية
أعرض في EDS

Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury.

التفاصيل البيبلوغرافية
العنوان: Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury.
المؤلفون: Nie X; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Liu Y; Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea., Yuan T; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Yu T; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Yun Z; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Xue W; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Yu T; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., An J; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Dai A; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Wu K; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China., Liu Q; Department of Orthopaedic, The second hospital of Jilin University, Changchun, China. qinyi@jlu.edu.cn.
المصدر: Journal of nanobiotechnology [J Nanobiotechnology] 2024 Jul 31; Vol. 22 (1), pp. 456. Date of Electronic Publication: 2024 Jul 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2003-
مواضيع طبية MeSH: Spinal Cord Injuries*/therapy , Exosomes*/metabolism , Platelet-Rich Plasma*/metabolism , Platelet-Rich Plasma*/chemistry , Spinal Cord*/metabolism , Neuroinflammatory Diseases*, Animals ; Mice ; Cell Line ; Male ; Mice, Inbred C57BL ; Blood-Brain Barrier/metabolism ; NF-kappa B/metabolism ; Tight Junctions/metabolism ; Inflammation ; Signal Transduction ; Female
مستخلص: Spinal cord injury (SCI) compromises the blood-spinal cord barrier (BSCB) and induces neuroinflammation, potentially exacerbating neuronal damage. This underscores the importance of maintaining BSCB integrity and mitigating neuroinflammation in SCI treatment. Our study explores an innovative approach to treating SCI by utilizing platelet-rich plasma-derived exosomes (PRP-Exos) to stabilize BSCB function and alleviate neuroinflammation. We successfully isolated exosomes from platelet-rich plasma and conducted both in vivo and in vitro experiments to assess the therapeutic effects of PRP-Exos and explore their potential mechanisms in stabilizing the BSCB, reducing neuroinflammation, and promoting neural functional recovery.In vitro results demonstrate that PRP-Exos significantly reduce the permeability of bEnd.3 cells under hypoxic-hypoglycemic conditions, thereby restoring the integrity of tight junctions. Additionally, our study elucidates the critical role of the NF-κB signaling pathway in the amelioration of neuroinflammation by PRP-Exos. In the SCI model, local injection of hydrogel-encapsulated PRP-Exos reduced Evans blue dye leakage, enhanced the expression of tight junction proteins, alleviated the inflammatory environment in the damaged area, and improved neural functional recovery. In conclusion, PRP-Exos presents a promising and effective treatment option for SCI.
(© 2024. The Author(s).)
References: J Orthop Surg Res. 2019 Dec 30;14(1):470. (PMID: 31888697)
Theranostics. 2017 Jan 1;7(1):81-96. (PMID: 28042318)
J Nanobiotechnology. 2022 Jan 29;20(1):56. (PMID: 35093078)
J Extra Corpor Technol. 2006 Jun;38(2):174-87. (PMID: 16921694)
Brain. 2023 Jul 3;146(7):2672-2693. (PMID: 36848323)
J Neurol Phys Ther. 2020 Jan;44(1):49-100. (PMID: 31834165)
Science. 2020 Feb 7;367(6478):. (PMID: 32029601)
Cell Transplant. 2021 Jan-Dec;30:9636897211017833. (PMID: 34006140)
J Adv Res. 2020 Aug 18;28:97-109. (PMID: 33364048)
Continuum (Minneap Minn). 2024 Feb 1;30(1):53-72. (PMID: 38330472)
Physiol Rev. 2018 Apr 1;98(2):881-917. (PMID: 29513146)
Signal Transduct Target Ther. 2023 Jun 26;8(1):245. (PMID: 37357239)
Stem Cell Res Ther. 2024 Jan 2;15(1):6. (PMID: 38167108)
J Nanobiotechnology. 2021 Nov 17;19(1):373. (PMID: 34789266)
Curr Neurol Neurosci Rep. 2019 Jul 30;19(9):65. (PMID: 31363857)
J Neurotrauma. 2021 May 1;38(9):1203-1224. (PMID: 33292072)
Theranostics. 2017 Jan 15;7(3):733-750. (PMID: 28255363)
Acta Biomater. 2021 May;126:211-223. (PMID: 33722788)
Cells. 2019 Jul 15;8(7):. (PMID: 31311206)
Eur J Pain. 2022 Jan;26(1):43-60. (PMID: 34288258)
Theranostics. 2018 Jan 1;8(1):237-255. (PMID: 29290805)
Cell Prolif. 2021 Dec;54(12):e13123. (PMID: 34609779)
Nano Lett. 2022 Aug 10;22(15):6391-6401. (PMID: 35876503)
Neurol Sci. 2021 Apr;42(4):1287-1299. (PMID: 33464411)
J Nanobiotechnology. 2024 Mar 12;22(1):108. (PMID: 38475766)
Int J Mol Sci. 2022 Mar 05;23(5):. (PMID: 35270001)
Adv Healthc Mater. 2024 Apr;13(9):e2302286. (PMID: 38056013)
ACS Nano. 2023 Sep 26;17(18):18008-18024. (PMID: 37695238)
Cell Biosci. 2023 Mar 13;13(1):55. (PMID: 36915206)
Int Immunopharmacol. 2022 Sep;110:108962. (PMID: 35753124)
AIMS Neurosci. 2023 Nov 20;10(4):332-353. (PMID: 38188010)
Cells. 2022 Aug 29;11(17):. (PMID: 36078099)
Front Neurosci. 2019 Apr 16;13:319. (PMID: 31040762)
Theranostics. 2020 Sep 14;10(25):11376-11403. (PMID: 33052221)
فهرسة مساهمة: Keywords: Blood-spinal cord barrier; Exosomes; Neuroinflammation; Platelet-rich plasma(PRP); Spinal cord injury
المشرفين على المادة: 0 (NF-kappa B)
تواريخ الأحداث: Date Created: 20240731 Date Completed: 20240801 Latest Revision: 20240803
رمز التحديث: 20240803
مُعرف محوري في PubMed: PMC11290287
DOI: 10.1186/s12951-024-02737-5
PMID: 39085856
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-3155
DOI:10.1186/s12951-024-02737-5