دورية أكاديمية
Unlocking the potential of edible Ulva sp. seaweeds: Metabolomic profiling, neuroprotective mechanisms, and implications for Parkinson's disease management.
العنوان: | Unlocking the potential of edible Ulva sp. seaweeds: Metabolomic profiling, neuroprotective mechanisms, and implications for Parkinson's disease management. |
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المؤلفون: | Abu-Baih DH; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Deraya University, Minya, Egypt.; Deraya Center for Scientific Research, Deraya University, New Minia City, Minia, Egypt., Abd El-Mordy FM; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Saber EA; Department of Medical Sciences, Deraya University, Minya, Egypt., Ali SFE; Department of Anatomy, Faculty of Medicine, Minya University, Minya, Egypt., Hisham M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New-Minia, Egypt., Alanazi MA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Altemani FH; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Algehainy NA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Lehmann L; Chair of Food Chemistry, Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany., Abdelmohsen UR; Deraya Center for Scientific Research, Deraya University, New Minia City, Minia, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt. |
المصدر: | Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Jul 31, pp. e2400418. Date of Electronic Publication: 2024 Jul 31. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2005->: Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA Original Publication: Weinheim, Verlag Chemie GmbH. |
مستخلص: | Green seaweed (Ulva sp.) is frequently used as a food component and nutraceutical agent because of its high polysaccharide and natural fiber content in Asian countries. This study investigates both metabolomic profiling of Ulva sp. and the neuroprotective efficacy of its ethanol extract and its underlying mechanisms in a rotenone-induced rat model of neurodegeneration, mimicking Parkinson's disease (PD) in humans. Metabolomic profiling of Ulva sp. extract was done using liquid chromatography high resolution electrospray ionization mass spectrometry and led to the identification of 22 compounds belonging to different chemical classes.Catenin Beta Additionally, this study demonstrated the neuroprotective properties against rotenone-induced PD, which was achieved through the suppression of elevated levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 together with the inhibition of reactive oxygen species (ROS) generation, apoptosis, inflammatory mediators, and the phosphoinositide 3-kinases/serine/threonine protein kinase (PI3K/AKT) pathway. Using a protein-protein interaction network, AKT1, GAPDH, TNF-α, IL-6, caspase 3, signal transducer and activator of transcription 3, Catenin Beta 1, epidermal growth factor receptor, B-cell lymphoma -2, and HSP90AA1 were identified as the top 10 most significant genes. Finally, molecular docking results showed that compounds 1, 3, and 7 might possess a promising anti-parkinsonism effect by binding to active sites of selected hub genes. Therefore, it is hypothesized that the Ulva sp. extract has the potential to be further developed as a potential therapeutic agent for the treatment of PD. (© 2024 Deutsche Pharmazeutische Gesellschaft.) |
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معلومات مُعتمدة: | None |
فهرسة مساهمة: | Keywords: Network pharmacology; PI3K/AKT pathway; Parkinson's disease; Protein‐protein interaction network; Ulva sp. |
تواريخ الأحداث: | Date Created: 20240801 Latest Revision: 20240801 |
رمز التحديث: | 20240801 |
DOI: | 10.1002/ardp.202400418 |
PMID: | 39086040 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1521-4184 |
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DOI: | 10.1002/ardp.202400418 |