دورية أكاديمية
Explore the genetic exposure to alopecia areata.
| العنوان: | Explore the genetic exposure to alopecia areata. |
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| المؤلفون: | Peng S; Department of Cardiology, Jiande First People's Hospital, Hangzhou, China., Yang Y; Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, China., Man Y; Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China., Long D; Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China., Wang L; Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China., Li K; Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China., Liu P; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. |
| المصدر: | Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) [Skin Res Technol] 2024 Aug; Vol. 30 (8), pp. e13874. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Country of Publication: England NLM ID: 9504453 Publication Model: Print Cited Medium: Internet ISSN: 1600-0846 (Electronic) Linking ISSN: 0909752X NLM ISO Abbreviation: Skin Res Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1998-> : Oxford : Blackwell Original Publication: Copenhagen, Denmark ; Cambridge, MA : Munksgaard, c1995- |
| مواضيع طبية MeSH: | Alopecia Areata*/genetics , Alopecia Areata*/blood , Genome-Wide Association Study* , Mendelian Randomization Analysis*, Humans ; Genetic Predisposition to Disease/genetics ; Trace Elements/blood ; Polymorphism, Single Nucleotide |
| مستخلص: | Background: Alopecia areata is an autoimmune hair loss disorder with an incompletely understood etiology. Although trace elements, serum metabolites, and inflammatory factors are implicated in the disease, the potential causal relationships between these factors and alopecia areata require further investigation. Methods: This study employed Mendelian randomization (MR), utilizing data from genome-wide association studies, to explore the causal relationships between 15 trace elements, 1400 serum metabolites, and 91 inflammatory factors and alopecia areata. The analysis was conducted using the inverse variance weighted (IVW) method complemented by various sensitivity analyses, including Cochran's Q test, MR-Egger regression intercept test, MR-PRESSO global test, and leave-one-out analysis, to assess the robustness of the results. Results: MR analysis indicated a negative correlation between copper levels and the risk of developing alopecia areata (odds ratio = 0.86, 95% confidence interval: 0.75-0.99, p = 0.041). Additionally, causal relationships were identified between 15 serum metabolites and 6 inflammatory factors and the risk of alopecia areata (IVW, all p values < 0.05). Conclusion: This study provides genetic evidence of the relationships between trace elements, serum metabolites, and alopecia areata, underscoring the potential value of targeted therapeutic strategies and preventive measures. Future research should expand to diverse populations and further explore the specific roles of these biomarkers in the disease mechanism. (© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: alopecia areata; inflammatory factors; mendelian randomization; serum metabolites; trace elements |
| المشرفين على المادة: | 0 (Trace Elements) |
| تواريخ الأحداث: | Date Created: 20240801 Date Completed: 20240801 Latest Revision: 20240803 |
| رمز التحديث: | 20240803 |
| مُعرف محوري في PubMed: | PMC11291861 |
| DOI: | 10.1111/srt.13874 |
| PMID: | 39086160 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-0846 |
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| DOI: | 10.1111/srt.13874 |