دورية أكاديمية
What It Takes To Be a Platelet: Evolving Concepts in Platelet Production.
| العنوان: | What It Takes To Be a Platelet: Evolving Concepts in Platelet Production. |
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| المؤلفون: | Carminita E; Vascular Biology Program, Boston Children's Hospital, Boston, MA (E.C., I.C.B., J.E.I.).; Harvard Medical School, Boston, MA (E.C., I.C.B.)., Becker IC; Vascular Biology Program, Boston Children's Hospital, Boston, MA (E.C., I.C.B., J.E.I.).; Harvard Medical School, Boston, MA (E.C., I.C.B.)., Italiano JE; Vascular Biology Program, Boston Children's Hospital, Boston, MA (E.C., I.C.B., J.E.I.). |
| المصدر: | Circulation research [Circ Res] 2024 Aug 02; Vol. 135 (4), pp. 540-549. Date of Electronic Publication: 2024 Aug 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore, MD : Lippincott Williams & Wilkins Original Publication: Baltimore, Md. Grune & Stratton. |
| مواضيع طبية MeSH: | Blood Platelets*/metabolism , Megakaryocytes*/cytology , Megakaryocytes*/metabolism , Thrombopoiesis*/physiology, Humans ; Animals |
| مستخلص: | Platelets are among the most abundant cells within the circulation. Given that the platelet lifespan is 7 to 10 days in humans, a constant production of around 100 billion platelets per day is required. Platelet production from precursor cells called megakaryocytes is one of the most enigmatic processes in human biology. Although it has been studied for over a century, there is still controversy about the exact mechanisms leading to platelet release into circulation. The formation of proplatelet extensions from megakaryocytes into bone marrow sinusoids is the best-described mechanism explaining the origin of blood platelets. However, using powerful imaging techniques, several emerging studies have recently raised challenging questions in the field, suggesting that small platelet-sized structures called buds might also contribute to the circulating platelet pool. How and whether these structures differ from microvesicles or membrane blebs, which have previously been described to be released from megakaryocytes, is still a matter of discussion. In this review, we will summarize what the past and present have revealed about platelet production and whether mature blood platelets might emerge via different mechanisms. Competing Interests: J.E. Italiano has a financial interest in and is a founder of Stellular Bio and Spry Bio. The interests of J.E. Italiano are managed by Boston Children’s Hospital. The other authors report no conflicts. |
| فهرسة مساهمة: | Keywords: blood platelets; bone marrow; megakaryocytes; platelet count |
| تواريخ الأحداث: | Date Created: 20240801 Date Completed: 20240801 Latest Revision: 20240801 |
| رمز التحديث: | 20240802 |
| DOI: | 10.1161/CIRCRESAHA.124.323579 |
| PMID: | 39088641 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4571 |
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| DOI: | 10.1161/CIRCRESAHA.124.323579 |