دورية أكاديمية
Mechanisms and regulation of replication fork reversal.
| العنوان: | Mechanisms and regulation of replication fork reversal. |
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| المؤلفون: | Adolph MB; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, United States., Cortez D; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, United States. Electronic address: david.cortez@vanderbilt.edu. |
| المصدر: | DNA repair [DNA Repair (Amst)] 2024 Sep; Vol. 141, pp. 103731. Date of Electronic Publication: 2024 Jul 22. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-7856 (Electronic) Linking ISSN: 15687856 NLM ISO Abbreviation: DNA Repair (Amst) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| مواضيع طبية MeSH: | DNA Damage Tolerance*, Animals ; Humans ; DNA/metabolism ; DNA Helicases/metabolism ; DNA Helicases/genetics ; DNA Repair ; Genomic Instability |
| مستخلص: | DNA replication is remarkably accurate with estimates of only a handful of mutations per human genome per cell division cycle. Replication stress caused by DNA lesions, transcription-replication conflicts, and other obstacles to the replication machinery must be efficiently overcome in ways that minimize errors and maximize completion of DNA synthesis. Replication fork reversal is one mechanism that helps cells tolerate replication stress. This process involves reannealing of parental template DNA strands and generation of a nascent-nascent DNA duplex. While fork reversal may be beneficial by facilitating DNA repair or template switching, it must be confined to the appropriate contexts to preserve genome stability. Many enzymes have been implicated in this process including ATP-dependent DNA translocases like SMARCAL1, ZRANB3, HLTF, and the helicase FBH1. In addition, the RAD51 recombinase is required. Many additional factors and regulatory activities also act to ensure reversal is beneficial instead of yielding undesirable outcomes. Finally, reversed forks must also be stabilized and often need to be restarted to complete DNA synthesis. Disruption or deregulation of fork reversal causes a variety of human diseases. In this review we will describe the latest models for reversal and key mechanisms of regulation. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: DNA damage; DNA replication; Fork protection; Fork reversal; Genome stability; Replication stress |
| المشرفين على المادة: | 9007-49-2 (DNA) EC 3.6.4.- (DNA Helicases) |
| تواريخ الأحداث: | Date Created: 20240801 Date Completed: 20240816 Latest Revision: 20240820 |
| رمز التحديث: | 20240820 |
| DOI: | 10.1016/j.dnarep.2024.103731 |
| PMID: | 39089193 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1568-7856 |
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| DOI: | 10.1016/j.dnarep.2024.103731 |