دورية أكاديمية
أعرض في EDS

A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma.

التفاصيل البيبلوغرافية
العنوان: A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma.
المؤلفون: Jeong BK; Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Korea.; Biomedical Research Center, KAIST, Daejeon, Korea., Choi WI; Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Korea.; Biomedical Research Center, KAIST, Daejeon, Korea., Choi W; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea. wonsuc1@uci.edu., Moon J; Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Korea.; Biomedical Research Center, KAIST, Daejeon, Korea., Lee WH; Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Korea.; Biomedical Research Center, KAIST, Daejeon, Korea., Choi C; Department of Pathology, Chonnam National University Medical School, Hwasun, Korea., Choi IY; Hanmi Research Center, Hanmi Pharmaceutical Co. Ltd, Hwaseong, Korea., Lee SH; Hanmi Research Center, Hanmi Pharmaceutical Co. Ltd, Hwaseong, Korea., Kim JK; Hanmi Research Center, Hanmi Pharmaceutical Co. Ltd, Hwaseong, Korea., Ju YS; Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Korea.; Biomedical Research Center, KAIST, Daejeon, Korea., Kim P; Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Korea.; Biomedical Research Center, KAIST, Daejeon, Korea., Moon YA; Department of Molecular Medicine, Inha University College of Medicine, Incheon, 22212, Korea., Park JY; Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital, Seoul, Korea. drpjy@yuhs.ac., Kim H; Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Korea. hailkim@kaist.edu.; Biomedical Research Center, KAIST, Daejeon, Korea. hailkim@kaist.edu.
المصدر: Nature communications [Nat Commun] 2024 Aug 02; Vol. 15 (1), pp. 6506. Date of Electronic Publication: 2024 Aug 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Disease Models, Animal* , Diet, High-Fat*/adverse effects, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Humans ; Liver/metabolism ; Liver/pathology ; Fatty Liver/metabolism ; Fatty Liver/pathology ; Streptozocin ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Transcriptome ; Obesity/metabolism ; Obesity/complications ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/complications
مستخلص: The lack of an appropriate preclinical model of metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole disease spectrum impedes exploration of disease pathophysiology and the development of effective treatment strategies. Here, we develop a mouse model (Streptozotocin with high-fat diet, STZ + HFD) that gradually develops fatty liver, metabolic dysfunction-associated steatohepatitis (MASH), hepatic fibrosis, and hepatocellular carcinoma (HCC) in the context of metabolic dysfunction. The hepatic transcriptomic features of STZ + HFD mice closely reflect those of patients with obesity accompanying type 2 diabetes mellitus, MASH, and MASLD-related HCC. Dietary changes and tirzepatide administration alleviate MASH, hepatic fibrosis, and hepatic tumorigenesis in STZ + HFD mice. In conclusion, a murine model recapitulating the main histopathologic, transcriptomic, and metabolic alterations observed in MASLD patients is successfully established.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 2020M3A9E403869513 National Research Foundation of Korea (NRF)
المشرفين على المادة: 5W494URQ81 (Streptozocin)
تواريخ الأحداث: Date Created: 20240801 Date Completed: 20240801 Latest Revision: 20240804
رمز التحديث: 20240804
مُعرف محوري في PubMed: PMC11294468
DOI: 10.1038/s41467-024-50660-y
PMID: 39090079
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-50660-y