دورية أكاديمية
أعرض في EDS

Evaluation of COVID-19 rapid antigen test against polymerase chain reaction test in immunocompromised patients.

التفاصيل البيبلوغرافية
العنوان: Evaluation of COVID-19 rapid antigen test against polymerase chain reaction test in immunocompromised patients.
المؤلفون: Sabateen A; Infectious Diseases Unit, Augusta Victoria Hospital, East Jerusalem, Palestine., Sadaqa D; Infectious Diseases Unit, Augusta Victoria Hospital, East Jerusalem, Palestine., Nino T; Molecular Laboratory, Augusta Victoria Hospital, East Jerusalem, Palestine., Zaghal G; Molecular Laboratory, Augusta Victoria Hospital, East Jerusalem, Palestine., Qumsieh G; Molecular Laboratory, Augusta Victoria Hospital, East Jerusalem, Palestine., Fakhori R; Molecular Laboratory, Augusta Victoria Hospital, East Jerusalem, Palestine., Rjoub H; Infectious Diseases Unit, Augusta Victoria Hospital, East Jerusalem, Palestine., Taha T; Infectious Diseases Unit, Augusta Victoria Hospital, East Jerusalem, Palestine., Zghari R; Infectious Diseases Unit, Augusta Victoria Hospital, East Jerusalem, Palestine., Abu Hanieh S; Infectious Diseases Unit, Augusta Victoria Hospital, East Jerusalem, Palestine., Al-Basha D; Infectious Diseases Unit, Augusta Victoria Hospital, East Jerusalem, Palestine.; Pharmacy Department, Modern University College (MUC), Ramallah, Palestine., Qabaja M; Pathology Laboratory, Augusta Victoria Hospital, East Jerusalem, Palestine., Alsaid H; Internal Medicine Department, Hadassah University Hospital, Jerusalem, Israel., Hindiyeh MY; Molecular Laboratory, Augusta Victoria Hospital, East Jerusalem, Palestine.
المصدر: PloS one [PLoS One] 2024 Aug 02; Vol. 19 (8), pp. e0306396. Date of Electronic Publication: 2024 Aug 02 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Immunocompromised Host* , COVID-19*/diagnosis , COVID-19*/immunology , COVID-19*/virology , SARS-CoV-2*/immunology , SARS-CoV-2*/isolation & purification , SARS-CoV-2*/genetics , Sensitivity and Specificity*, Humans ; Middle Aged ; Female ; Male ; Adult ; Aged ; Young Adult ; Adolescent ; Polymerase Chain Reaction/methods ; COVID-19 Serological Testing/methods ; Aged, 80 and over ; Antigens, Viral/immunology ; False Negative Reactions
مستخلص: On the 11th of March 2020, the world faced a new global pandemic, COVID-19 which is a disease caused by the novel coronavirus, it had multiple devastating outcomes on multiple sectors along with significant rates of mortality. These challenges encouraged the development of multiple testing methods, as well as anti-viral medications such as Molnupiravir, as well as evaluating the efficacy of available medications against it, like; Azithromycin, Ritonavir and Hydroxychloroquine. Vaccination against COVID-19 forged into a significant challenge, few months ensuing the first case of SARS-CoV-2, which was diagnosed in December 2019, in Wuhan-China, thus, multiple vaccines were approved for use around the world to combat this pandemic. Our study includes a sample of 556 oncology patients at Augusta Victoria Hospital in Jerusalem, all patients were tested using Panbio rapid antigen test and Allplex PCR Assay. The main objective was to study the sensitivity and specificity of Rapid antigen test, which contributes to a faster isolation call and management of infected patients, thus decreasing the risk on spread to other patients and health care. Patients were categorized based on two factors: Ct range and age group and studying their possible effect on false-negative results. Patients with Ct value less than 20, had the highest detection rate which is consistent with other studies in the literature. The sensitivity and specificity of Panbio Rapid Antigen testing were of 69.9% and 100%, respectively. A correlation between age group and false negative results could not be made, but a correlation between Ct value and false negative result was noticed, Ct value was directly related to false negative results. P-value of 0.007 indicated that results were statistically significant where PCR test is considered more sensitive compared to rapid antigen test.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Sabateen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: 0 (Antigens, Viral)
تواريخ الأحداث: Date Created: 20240802 Date Completed: 20240802 Latest Revision: 20240804
رمز التحديث: 20240804
مُعرف محوري في PubMed: PMC11296623
DOI: 10.1371/journal.pone.0306396
PMID: 39093858
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0306396