دورية أكاديمية
أعرض في EDS

Clinical and laboratory profile of patients with positive direct antiglobulin test attended at a university hospital in Goias, Brazil.

التفاصيل البيبلوغرافية
العنوان: Clinical and laboratory profile of patients with positive direct antiglobulin test attended at a university hospital in Goias, Brazil.
المؤلفون: Mendes IC; Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil. Electronic address: isadora.biomed.mendes@gmail.com., de Assis PCGF; Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil., de Almeida RS; Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil., de Sousa LRR; Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil., Carneiro LC; Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil., Jesuino RSA; Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
المصدر: Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2024 May 08. Date of Electronic Publication: 2024 May 08.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Editora Ltda Country of Publication: Brazil NLM ID: 101725732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2531-1387 (Electronic) Linking ISSN: 25311379 NLM ISO Abbreviation: Hematol Transfus Cell Ther
أسماء مطبوعة: Original Publication: [Rio de Janeiro, Brazil] : Elsevier Editora Ltda, [2018]-
مستخلص: Objective: To clinically and laboratory characterize patients with a positive direct antiglobulin test (DAT) treated at the Hospital das Clínicas of the Federal University of Goiás (HC-UFG).
Methods: A retrospective, descriptive, cross-sectional study was carried out collecting data from medical records of patients with a positive DAT who were treated at HC-UFG between August 2021 and August 2022.
Results: Eighty-four patients with positive polyspecific DAT results were screened in the clinical laboratory. Fifty-four patients had a laboratory profile compatible with autoimmune hemolytic anemia (AIHA), however, among these, 16 patients already had a diagnosis of AIHA in their medical records. The most common symptoms present among AIHA patients were pallor, asthenia, fatigue and dyspnea. For the remaining patients, the most common symptoms were severe thrombocytopenia, anemia, renal dysfunction, fever, myalgia, headache, thrombosis, asthenia, hematuria and joint pain. Only one patient had primary AIHA, that is, he had no evident underlying disease. The majority of AIHA patients (75 %) underwent corticosteroid therapy with 60 % having a positive response. For patients without AIHA, prednisone was the most frequently prescribed medication in 17 (25 %) patients, followed by hydroxychloroquine (14 patients - 20.1 %).
Conclusion: It is essential to evaluate patients with positive DAT in detail in order to understand the real clinical case. The DAT serological result alone does not arrive at a conclusive diagnosis of AIHA, and so it must be evaluated in conjunction with both clinical data and other laboratory tests, such as hemoglobin concentration and hemolysis tests (reticulocytes, lactate dehydrogenase and/or haptoglobin).
Competing Interests: Conflicts of interest The authors declare no conflicts of interest.
(Copyright © 2024 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. All rights reserved.)
فهرسة مساهمة: Keywords: Autoimmune hemolytic anemia; Direct antiglobulin test; Immunohematology
تواريخ الأحداث: Date Created: 20240802 Latest Revision: 20240802
رمز التحديث: 20240803
DOI: 10.1016/j.htct.2024.04.118
PMID: 39095314
قاعدة البيانات: MEDLINE
الوصف
تدمد:2531-1387
DOI:10.1016/j.htct.2024.04.118