دورية أكاديمية
A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.
| العنوان: | A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice. |
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| المؤلفون: | Decoster L; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France., Trova S; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France.; Centro CMP3VdA, Istituto Italiano di Tecnologia (IIT), Aosta, Italy., Zucca S; Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.; Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy., Bulk J; Max Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany., Gouveia A; Max Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany., Ternier G; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France., Lhomme T; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France., Legrand A; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France., Gallet S; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France., Boehm U; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Center for Gender-specific Biology and Medicine (CGBM), Saarland University School of Medicine, Homburg, Germany., Wyatt A; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Center for Gender-specific Biology and Medicine (CGBM), Saarland University School of Medicine, Homburg, Germany., Wahl V; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Center for Gender-specific Biology and Medicine (CGBM), Saarland University School of Medicine, Homburg, Germany., Wartenberg P; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Center for Gender-specific Biology and Medicine (CGBM), Saarland University School of Medicine, Homburg, Germany., Hrabovszky E; Laboratory of Reproductive Neurobiology, Hun-Ren Institute of Experimental Medicine, Budapest, Hungary., Rácz G; Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Luzzati F; Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.; Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy., Nato G; Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy.; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy., Fogli M; Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.; Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy., Peretto P; Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.; Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy., Schriever SC; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit Neurobiology of Diabetes, Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Bernecker M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit Neurobiology of Diabetes, Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany.; Division of Neurobiology of Diabetes, TUM School of Medicine, Technical University of Munich, Munich, Germany., Pfluger PT; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit Neurobiology of Diabetes, Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany.; Division of Neurobiology of Diabetes, TUM School of Medicine, Technical University of Munich, Munich, Germany., Steculorum SM; Max Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Bovetti S; Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.; Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy., Rasika S; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France., Prevot V; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France., Silva MSB; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France.; Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Giacobini P; Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, School of Medicine, Lille, France. paolo.giacobini@inserm.fr.; Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Labex DistAlz, Lille, France. paolo.giacobini@inserm.fr. |
| المصدر: | Nature neuroscience [Nat Neurosci] 2024 Sep; Vol. 27 (9), pp. 1758-1773. Date of Electronic Publication: 2024 Aug 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002->: New York, NY : Nature Publishing Group Original Publication: New York, NY : Nature America Inc., c1998- |
| مواضيع طبية MeSH: | Gonadotropin-Releasing Hormone*/metabolism , Olfactory Bulb*/physiology , Olfactory Bulb*/metabolism , Odorants* , Neurons*/metabolism , Neurons*/physiology , Sexual Behavior, Animal*/physiology , Vomeronasal Organ*/physiology , Vomeronasal Organ*/metabolism, Animals ; Male ; Mice ; Female ; Mice, Inbred C57BL ; Smell/physiology ; Amygdala/metabolism ; Amygdala/physiology |
| مستخلص: | Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and integrate hormonal status with environmental cues to ensure reproductive success. Here we show that GnRH neurons in the olfactory bulb (GnRH OB ) of adult mice can mediate social recognition. Specifically, we show that GnRH OB neurons extend neurites into the vomeronasal organ and olfactory epithelium and project to the median eminence. GnRH OB neurons in males express vomeronasal and olfactory receptors, are activated by female odors and mediate gonadotropin release in response to female urine. Male preference for female odors required the presence and activation of GnRH OB neurons, was impaired after genetic inhibition or ablation of these cells and relied on GnRH signaling in the posterodorsal medial amygdala. GnRH receptor expression in amygdala kisspeptin neurons appear to be required for GnRH OB neurons' actions on male mounting behavior. Taken together, these results establish GnRH OB neurons as regulating fertility, sex recognition and mating in male mice. (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.) |
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| معلومات مُعتمدة: | 725149 EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council); ANR-19-CE16-0021-02 Agence Nationale de la Recherche (French National Research Agency); ANR-18-CE14-00 Agence Nationale de la Recherche (French National Research Agency) |
| المشرفين على المادة: | 33515-09-2 (Gonadotropin-Releasing Hormone) |
| تواريخ الأحداث: | Date Created: 20240802 Date Completed: 20240904 Latest Revision: 20240912 |
| رمز التحديث: | 20240913 |
| DOI: | 10.1038/s41593-024-01724-1 |
| PMID: | 39095587 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1546-1726 |
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| DOI: | 10.1038/s41593-024-01724-1 |