دورية أكاديمية
Dietary and circulating branched chain amino acids are unfavorably associated with body fat measures among Chinese adults.
| العنوان: | Dietary and circulating branched chain amino acids are unfavorably associated with body fat measures among Chinese adults. |
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| المؤلفون: | Zhang Y; Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Anhui, China; NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, Anhui, China., Rao S; Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, China., Zhang X; Department of Physical Examination Center, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Peng Z; Department of Interventional Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Song W; Department of Interventional Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Xie S; Department of Chronic Non-communicable Diseases Prevention and Control, Lu'an Municipal Center for Disease Control and Prevention, Lu'an, Anhui, China., Cao H; Department of Chronic Non-communicable Diseases Prevention and Control, Lu'an Municipal Center for Disease Control and Prevention, Lu'an, Anhui, China., Zhang Z; Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, China., Yang W; Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Anhui, China; NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, Anhui, China. Electronic address: wanshuiyang@gmail.com. |
| المصدر: | Nutrition research (New York, N.Y.) [Nutr Res] 2024 Aug; Vol. 128, pp. 94-104. Date of Electronic Publication: 2024 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8303331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0739 (Electronic) Linking ISSN: 02715317 NLM ISO Abbreviation: Nutr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004- > : Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon Press, c1981- |
| مواضيع طبية MeSH: | Amino Acids, Branched-Chain*/blood , Amino Acids, Branched-Chain*/administration & dosage , Obesity*/blood , Body Mass Index* , Diet* , Adipose Tissue*/metabolism, Humans ; Male ; Female ; Middle Aged ; Adult ; China ; Body Composition ; Longitudinal Studies ; Soy Foods ; Asian People ; Body Weight ; Liver/metabolism ; Waist Circumference ; Aged ; East Asian People |
| مستخلص: | Animal studies showed a detrimental effect of dietary branched chain amino acids (BCAAs) on metabolic health, while epidemiological evidence on dietary BCAAs and obesity is limited and inconclusive. We hypothesized that high dietary and circulating BCAAs are unfavorably associated with obesity in community-dwelling adults. We evaluated the 1-year longitudinal associations of dietary BCAA intake and circulating BCAAs with body fat measures. Body weight, height, and circumferences of the waist (WC) and hip (HC) were measured at baseline and again after 1-year. Body composition and liver fat [indicated by controlled attenuation parameter (CAP)] were also assessed after 1-year. Serum BCAA concentrations at baseline were quantified by liquid chromatography mass spectrometry. Diet was collected using 4 quarterly 3-day recalls during the 1-year. The correlation coefficients between dietary and serum BCAAs were 0.12 (P = .035) for total dietary BCAAs, and ranged from -0.02 (soy foods, P = .749) to 0.18 (poultry, P = .001). Total dietary BCAA intake was associated with increase in body weight (β = 0.044, P = .022) and body mass index (BMI, β = 0.047, P = .043). BCAAs from animal foods were associated with increase in HC, while BCAAs from soy foods were associated with weight gain and higher CAP (all P < .05). Serum BCAAs were associated with higher WC, HC, BMI, body fat mass, visceral fat level, and CAP (all P < .05). These results support that dietary and circulating BCAAs are positively associated with the risk of obesity. More cohort studies with validated dietary assessment tools and long-term follow-up among diverse populations are needed to confirm our findings. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Body fat measures; Branched chain amino acids; Diet; Insulin resistance; Longitudinal study |
| المشرفين على المادة: | 0 (Amino Acids, Branched-Chain) |
| تواريخ الأحداث: | Date Created: 20240803 Date Completed: 20240816 Latest Revision: 20240816 |
| رمز التحديث: | 20240818 |
| DOI: | 10.1016/j.nutres.2024.06.009 |
| PMID: | 39096661 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-0739 |
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| DOI: | 10.1016/j.nutres.2024.06.009 |