دورية أكاديمية
Metabolomic and biochemical disorders reveal the toxicity of environmental microplastics and benzo[a]pyrene in the marine polychaete Hediste diversicolor.
| العنوان: | Metabolomic and biochemical disorders reveal the toxicity of environmental microplastics and benzo[a]pyrene in the marine polychaete Hediste diversicolor. |
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| المؤلفون: | Abouda S; Laboratory of Agrobiodiversity and Ecotoxicology, Higher Institute of Agronomy, University of Sousse, Sousse, Tunisia; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; Higher Institute of Biotechnology, University of Monastir, Monastir, Tunisia., Galati M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy., Oliveri Conti G; Interdepartmental Research Center for the Implementation of Physical, Chemical and Biological Monitoring Processes in Aquaculture and Bioremediation Systems, Department of Medical, Surgical and Advanced Technologies, Hygiene and Public Health 'G.F. Ingrassia', University of Catania, Catania, Italy., Cappello T; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy. Electronic address: tcappello@unime.it., Abelouah MR; Laboratory of Aquatic Systems: Marine and Continental Environments, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco., Romdhani I; Laboratory of Agrobiodiversity and Ecotoxicology, Higher Institute of Agronomy, University of Sousse, Sousse, Tunisia., Ait Alla A; Laboratory of Aquatic Systems: Marine and Continental Environments, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco., Ferrante M; Interdepartmental Research Center for the Implementation of Physical, Chemical and Biological Monitoring Processes in Aquaculture and Bioremediation Systems, Department of Medical, Surgical and Advanced Technologies, Hygiene and Public Health 'G.F. Ingrassia', University of Catania, Catania, Italy., Maisano M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy., Banni M; Laboratory of Agrobiodiversity and Ecotoxicology, Higher Institute of Agronomy, University of Sousse, Sousse, Tunisia. |
| المصدر: | Journal of hazardous materials [J Hazard Mater] 2024 Sep 15; Vol. 477, pp. 135404. Date of Electronic Publication: 2024 Aug 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, |
| مواضيع طبية MeSH: | Polychaeta*/drug effects , Polychaeta*/metabolism , Benzo(a)pyrene*/toxicity , Benzo(a)pyrene*/metabolism , Water Pollutants, Chemical*/toxicity , Microplastics*/toxicity , Metabolomics*, Animals ; Oxidative Stress/drug effects ; Geologic Sediments/chemistry |
| مستخلص: | Recently, the abundance of environmental microplastics (MPs) has become a global paramount concern. Besides the danger of MPs for biota due to their tiny size, these minute particles may act as vectors of other pollutants. This study focused on evaluating the toxicity of environmentally relevant concentrations of MPs (10 and 50 mg/kg sediment) and benzo[a]pyrene (B[a]P, 1 µg/kg sediment), alone and in mixture, for 3 and 7 days in marine polychaete Hediste diversicolor, selected as a benthic bioindicator model. The exposure period was sufficient to confirm the bioaccumulation of both contaminants in seaworms, as well as the potential capacity of plastic particles to adsorb and vehiculate the B[a]P. Interestingly, increase of acidic mucus production was observed in seaworm tissues, indicative of a defense response. The activation of oxidative system pathways was demonstrated as a strategy to prevent lipid peroxidation. Furthermore, the comprehensive Nuclear Magnetic Resonance (NMR)-based metabolomics revealed significant disorders in amino acids metabolism, osmoregulatory process, energetic components, and oxidative stress related elements. Overall, these findings proved the possible synergic harmful effect of MPs and B[a]P even in small concentrations, which increases the concern about their long-term presence in marine ecosystems, and consequently their transfer and repercussions on marine fauna. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Benzo[a]pyrene; Environmental microplastics; NMR-based metabolomics; Oxidative stress biomarkers; Seaworms |
| المشرفين على المادة: | 3417WMA06D (Benzo(a)pyrene) 0 (Water Pollutants, Chemical) 0 (Microplastics) |
| تواريخ الأحداث: | Date Created: 20240804 Date Completed: 20240816 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| DOI: | 10.1016/j.jhazmat.2024.135404 |
| PMID: | 39098204 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3336 |
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| DOI: | 10.1016/j.jhazmat.2024.135404 |