دورية أكاديمية
Radiation exposure of the glandular mammary tissue in women patients with mediastinal Hodgkin lymphoma treated with protons.
| العنوان: | Radiation exposure of the glandular mammary tissue in women patients with mediastinal Hodgkin lymphoma treated with protons. |
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| المؤلفون: | Loap P; Department of Radiation Oncology, institut Curie, Paris, France. Electronic address: pierre.loap@gmail.com., Goudjil F; Department of Radiation Oncology, institut Curie, Paris, France., Kirova Y; Department of Radiation Oncology, institut Curie, Paris, France. |
| المصدر: | Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2024 Aug; Vol. 28 (4), pp. 380-384. Date of Electronic Publication: 2024 Aug 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: France NLM ID: 9711272 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1769-6658 (Electronic) Linking ISSN: 12783218 NLM ISO Abbreviation: Cancer Radiother Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Paris : Elsevier, c1997- |
| مواضيع طبية MeSH: | Hodgkin Disease*/radiotherapy , Mediastinal Neoplasms*/radiotherapy , Organs at Risk*/radiation effects , Proton Therapy*/adverse effects , Proton Therapy*/methods , Breast Neoplasms*/radiotherapy, Humans ; Female ; Adult ; Retrospective Studies ; Middle Aged ; Young Adult ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Breast/radiation effects ; Breast/diagnostic imaging ; Radiotherapy Dosage ; Radiation Exposure ; Organ Sparing Treatments/methods ; Breath Holding ; Neoplasms, Radiation-Induced/etiology |
| مستخلص: | Purpose: Secondary breast cancer is a frequent late adverse event of mediastinal Hodgkin lymphoma radiotherapy. Secondary breast cancers overwhelmingly correspond to ductal carcinoma and develop from the glandular mammary tissue. In addition, during childhood, radiation overexposure of the glandular tissue may lead to a late breast hypotrophy at adult age. The aim of this study was to evaluate the radiation exposure to the glandular tissue in patients treated for mediastinal Hodgkin lymphoma with intensity-modulated proton therapy, in order to evaluate the potential dosimetric usefulness of its delineation for breast sparing. Materials and Methods: Sixteen consecutive intermediate-risk mediastinal female patients with Hodgkin lymphoma treated with consolidation radiation with deep inspiration breath hold intensity-modulated proton therapy to the total dose of 30Gy were included. Breasts were delineated according to the European Society for Radiotherapy and Oncology guidelines for treatment optimization ("clinical organ at risk"). The glandular tissue ("glandular organ at risk") was retrospectively contoured on the initial simulation CT scans based on Hounsfield unit (HU) values, using a range between -80HU and 500HU. Results: The mean and maximum doses delivered to the glandular organ at risk were significantly lower than the mean and maximum doses delivered to the clinical organ at risk, but were statistically correlated. Glandular organ at risk volumes were significantly smaller. Conclusion: Optimizing the treatment plans on the clinical breast contours will systematically lead to overestimation of the dose received to the glandular tissue and, consequently, to an indistinct and involuntary improved glandular tissue sparing. As such, our findings do not support the consideration of the glandular tissue as an additional organ at risk when planning intensity-modulated proton therapy for mediastinal Hodgkin lymphoma in female patients. (Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast cancer; Cancer; Hodgkin lymphoma; Lymphome de Hodgkin; Proton therapy; Protonthérapie; Sein |
| تواريخ الأحداث: | Date Created: 20240804 Date Completed: 20240831 Latest Revision: 20240831 |
| رمز التحديث: | 20240901 |
| DOI: | 10.1016/j.canrad.2024.04.002 |
| PMID: | 39098509 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1769-6658 |
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| DOI: | 10.1016/j.canrad.2024.04.002 |