دورية أكاديمية
أعرض في EDS

Combining Bifidobacterium longum subsp. infantis and human milk oligosaccharides synergistically increases short chain fatty acid production ex vivo.

التفاصيل البيبلوغرافية
العنوان: Combining Bifidobacterium longum subsp. infantis and human milk oligosaccharides synergistically increases short chain fatty acid production ex vivo.
المؤلفون: De Bruyn F; Nestlé Research and Development, Nestléstrasse 3, CH-3510, Konolfingen, Switzerland. florac.debruyn@rd.nestle.com., James K; Nestlé Research and Development, Nestléstrasse 3, CH-3510, Konolfingen, Switzerland., Cottenet G; Nestlé Institute of Food Safety and Analytical Science, Nestlé Research, Route du Jorat 57, CH-1000, Lausanne, Switzerland., Dominick M; Nestlé Research and Development, Nestléstrasse 3, CH-3510, Konolfingen, Switzerland., Katja J; Nestlé Research and Development, Nestléstrasse 3, CH-3510, Konolfingen, Switzerland.
المصدر: Communications biology [Commun Biol] 2024 Aug 04; Vol. 7 (1), pp. 943. Date of Electronic Publication: 2024 Aug 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
مواضيع طبية MeSH: Milk, Human*/metabolism , Milk, Human*/chemistry , Oligosaccharides*/metabolism , Fatty Acids, Volatile*/metabolism , Bifidobacterium longum subspecies infantis*/metabolism, Humans ; Infant ; Bifidobacterium/metabolism ; Probiotics/administration & dosage ; Gastrointestinal Microbiome ; Feces/microbiology ; Female ; Synbiotics/administration & dosage ; Child, Preschool
مستخلص: To enhance health benefits, a probiotic can be co-administered with a metabolizable prebiotic forming a synergistic synbiotic. We assessed the synergies resulting from combining Bifidobacterium longum subsp. infantis LMG 11588 and an age-adapted blend of six human milk oligosaccharides (HMOs) in ex vivo colonic incubation bioreactors seeded with fecal background microbiota from infant and toddler donors. When HMOs were combined with B. infantis LMG 11588, they were rapidly and completely consumed. This resulted in increased short chain fatty acid (SCFA) production compared to the summed SCFA production from individual ingredients (synergy). Remarkably, HMOs were partially consumed for specific infant donors in the absence of B. infantis LMG 11588, yet all donors showed increased SCFA production upon B. infantis LMG 11588 supplementation. We found specific bacterial taxa associated with the differential response pattern to HMOs. Our study shows the importance of carefully selecting pre- and probiotic into a synergistic synbiotic that could benefit infants.
(© 2024. The Author(s).)
References: Nutrients. 2016 Jun 08;8(6):. (PMID: 27338459)
Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):687-701. (PMID: 32826966)
Front Nutr. 2022 Aug 04;9:935711. (PMID: 35990340)
Sci Rep. 2020 Sep 28;10(1):15919. (PMID: 32985563)
Nucleic Acids Res. 2013 Jan 7;41(1):e1. (PMID: 22933715)
Pediatrics. 2005 Jan;115(1):5-9. (PMID: 15629974)
Front Nutr. 2023 Dec 14;10:1319873. (PMID: 38162520)
Nat Commun. 2016 Jun 24;7:11939. (PMID: 27340092)
BMC Res Notes. 2017 Jul 26;10(1):325. (PMID: 28747215)
J Agric Food Chem. 2007 Oct 31;55(22):8914-9. (PMID: 17915960)
Glycobiology. 2013 Nov;23(11):1281-92. (PMID: 24013960)
Nutrients. 2019 Jun 05;11(6):. (PMID: 31195757)
Nutrients. 2022 Mar 29;14(7):. (PMID: 35406036)
Microbiology (Reading). 2010 Nov;156(Pt 11):3329-3341. (PMID: 20864478)
Cell Host Microbe. 2011 Nov 17;10(5):507-14. (PMID: 22036470)
Res Microbiol. 2013 May;164(4):288-92. (PMID: 23376087)
Int J Mol Sci. 2022 Feb 28;23(5):. (PMID: 35269818)
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15;1124:188-196. (PMID: 31212236)
Pediatr Diabetes. 2018 Dec;19(8):1400-1406. (PMID: 30136344)
Front Nutr. 2020 Oct 29;7:574459. (PMID: 33195368)
Environ Microbiol. 2017 Aug;19(8):3251-3267. (PMID: 28618173)
Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
Int J Food Microbiol. 2011 Sep 1;149(1):58-64. (PMID: 21342711)
Nutrients. 2020 Jul 29;12(8):. (PMID: 32751149)
Appl Environ Microbiol. 2003 Mar;69(3):1511-20. (PMID: 12620837)
Appl Environ Microbiol. 2020 May 19;86(11):. (PMID: 32276972)
Sci Rep. 2016 Oct 19;6:35045. (PMID: 27756904)
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18964-9. (PMID: 19033196)
Science. 2013 Aug 2;341(6145):569-73. (PMID: 23828891)
Appl Environ Microbiol. 2010 Nov;76(22):7373-81. (PMID: 20802066)
Front Endocrinol (Lausanne). 2020 Jan 31;11:25. (PMID: 32082260)
Front Nutr. 2022 Jul 06;9:920362. (PMID: 35873420)
Front Microbiol. 2016 May 19;7:713. (PMID: 27242734)
Front Nutr. 2020 Nov 24;7:583397. (PMID: 33330584)
Microbiome. 2017 Jan 17;5(1):4. (PMID: 28095889)
Microorganisms. 2022 Jan 18;10(2):. (PMID: 35208658)
Environ Microbiol. 2018 Jun;20(6):2256-2269. (PMID: 29786169)
Sci Rep. 2019 May 28;9(1):7983. (PMID: 31138818)
Pediatr Res. 2008 Oct;64(4):418-22. (PMID: 18552710)
Microorganisms. 2021 Mar 27;9(4):. (PMID: 33801755)
PLoS Genet. 2014 Jun 05;10(6):e1004406. (PMID: 24901968)
Trends Microbiol. 2010 Jul;18(7):298-307. (PMID: 20409714)
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283)
Front Microbiol. 2017 Jan 30;8:95. (PMID: 28194144)
Br J Nutr. 2015 May 14;113(9):1339-44. (PMID: 25989994)
Science. 2022 Jun 10;376(6598):1220-1223. (PMID: 35679413)
Front Nutr. 2023 Oct 03;10:1239349. (PMID: 37854348)
Cell. 2022 Nov 10;185(23):4280-4297.e12. (PMID: 36323316)
Gut Microbes. 2017 Mar 4;8(2):172-184. (PMID: 28165863)
J Nutr. 2021 Apr 8;151(4):876-882. (PMID: 33693851)
Sci Rep. 2019 Aug 13;9(1):11767. (PMID: 31409852)
Cell Host Microbe. 2023 Apr 12;31(4):485-499. (PMID: 37054671)
Adv Nutr. 2012 May 01;3(3):415S-21S. (PMID: 22585920)
PLoS One. 2012;7(5):e36957. (PMID: 22606315)
Front Immunol. 2019 Mar 11;10:277. (PMID: 30915065)
BMC Microbiol. 2016 Oct 26;16(1):248. (PMID: 27782805)
Anal Chim Acta. 2018 Jun 20;1010:86-96. (PMID: 29447675)
Clin Microbiol Infect. 2012 Jul;18 Suppl 4:12-5. (PMID: 22647041)
ISME J. 2022 Sep;16(9):2265-2279. (PMID: 35768643)
ISME J. 2020 Feb;14(2):635-648. (PMID: 31740752)
Appl Microbiol Biotechnol. 1993 May;39(2):254-8. (PMID: 7763732)
J Pediatr Gastroenterol Nutr. 2004 Mar;38(3):288-92. (PMID: 15076628)
Pediatr Res. 2015 Jan;77(1-2):229-35. (PMID: 25303277)
J Mol Biol. 1990 Oct 5;215(3):403-10. (PMID: 2231712)
PLoS One. 2017 Feb 9;12(2):e0171814. (PMID: 28182762)
المشرفين على المادة: 0 (Oligosaccharides)
0 (Fatty Acids, Volatile)
تواريخ الأحداث: Date Created: 20240804 Date Completed: 20240804 Latest Revision: 20240807
رمز التحديث: 20240807
مُعرف محوري في PubMed: PMC11298527
DOI: 10.1038/s42003-024-06628-1
PMID: 39098939
قاعدة البيانات: MEDLINE
الوصف
تدمد:2399-3642
DOI:10.1038/s42003-024-06628-1